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- NCIT_C189084 IAO_0000115 "A preparation of autologous T-lymphocytes that have been engineered to express a chimeric autoantibody receptor (CAAR) containing the autoantigen muscle, skeletal receptor tyrosine-protein kinase (MuSK; muscle-specific kinase) that is fused to the co-stimulatory domain of 4-1BB (CD137) and the T-cell receptor signaling domain of CD3zeta (CD3z), with potential immunomodulatory activity. Upon administration, the autologous MuSK-CD3z/4-1BB-expressing CAAR T-cells MuSK-CAART specifically recognize and induce selective toxicity in aberrant B-cells expressing MuSK autoantibodies. This inhibits the production of MuSK autoantibodies. MuSK is a transmembrane protein expressed on skeletal muscle cell membrane that plays an important role in the formation and maintenance of the neuromuscular junction. MuSK autoantibodies are produced and expressed by aberrant B-cells in MuSK-associated myasthenia gravis." @default.
- NCIT_C189084 NCIT_A7 NCIT_C28528 @default.
- NCIT_C189084 NCIT_NHC0 "C189084" @default.
- NCIT_C189084 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189084 NCIT_P108 "Autologous MuSK-CD3z/4-1BB-expressing Chimeric Autoantibody Receptor T-cells MuSK-CAART" @default.
- NCIT_C189084 NCIT_P208 "CL1794292" @default.
- NCIT_C189084 NCIT_P399 "810280" @default.
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- NCIT_C189084 NCIT_R72 NCIT_C21599 @default.
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- NCIT_C189084 NCIT_R72 NCIT_C33061 @default.
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- NCIT_C189084 normalizedInformationContent "100" @default.
- NCIT_C189084 referenceCount "1" @default.
- NCIT_C189084 hasExactSynonym "Autologous Anti-MuSK-CD3z/4-1BB-expressing CAART MuSK-CAART" @default.
- NCIT_C189084 hasExactSynonym "Autologous MuSK CAAR T-cells MuSK-CAART" @default.
- NCIT_C189084 hasExactSynonym "Autologous MuSK CAAR-expressing T-cells MuSK-CAART" @default.
- NCIT_C189084 hasExactSynonym "Autologous MuSK-CD3z/4-1BB-expressing CAAR T-cells MuSK-CAART" @default.
- NCIT_C189084 hasExactSynonym "Autologous MuSK-CD3z/4-1BB-expressing CAART MuSK-CAART" @default.
- NCIT_C189084 hasExactSynonym "Autologous MuSK-CD3z/4-1BB-expressing Chimeric Autoantibody Receptor T-cells MuSK-CAART" @default.
- NCIT_C189084 hasExactSynonym "MuSK-CAART" @default.
- NCIT_C189084 inSubset NCIT_C176424 @default.
- NCIT_C189084 type Class @default.
- NCIT_C189084 isDefinedBy ncit.owl @default.
- NCIT_C189084 label "Autologous MuSK-CD3z/4-1BB-expressing Chimeric Autoantibody Receptor T-cells MuSK-CAART" @default.
- NCIT_C189084 subClassOf NCIT_C142078 @default.
- NCIT_C189084 subClassOf NCIT_C189084 @default.
- NCIT_C189084 subClassOf NCIT_C1908 @default.
- NCIT_C189084 subClassOf NCIT_C1909 @default.
- NCIT_C189084 subClassOf NCIT_C28681 @default.
- NCIT_C189084 subClassOf NCIT_C307 @default.
- NCIT_C189084 subClassOf NCIT_C308 @default.