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- NCIT_C189085 IAO_0000115 "An orally bioavailable, mutant-selective, fourth-generation epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration, EGFR mutant-selective inhibitor HS-10375 targets, binds to and inhibits the activity of EGFR with C797S mutations, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. HS-10375 inhibits EGFR with C797S mutations, which prevents covalent bond formation with third-generation EGFR inhibitors leading to drug resistance." @default.
- NCIT_C189085 NCIT_A7 NCIT_C147011 @default.
- NCIT_C189085 NCIT_NHC0 "C189085" @default.
- NCIT_C189085 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189085 NCIT_P108 "EGFR Mutant-selective Inhibitor HS-10375" @default.
- NCIT_C189085 NCIT_P208 "CL1794291" @default.
- NCIT_C189085 NCIT_P322 "GDC" @default.
- NCIT_C189085 NCIT_P399 "810253" @default.
- NCIT_C189085 normalizedInformationContent "100" @default.
- NCIT_C189085 referenceCount "1" @default.
- NCIT_C189085 hasExactSynonym "EGFR C797S Inhibitor HS-10375" @default.
- NCIT_C189085 hasExactSynonym "EGFR Mutant-selective Inhibitor HS-10375" @default.
- NCIT_C189085 hasExactSynonym "HS 10375" @default.
- NCIT_C189085 hasExactSynonym "HS-10375" @default.
- NCIT_C189085 hasExactSynonym "HS10375" @default.
- NCIT_C189085 inSubset NCIT_C128784 @default.
- NCIT_C189085 inSubset NCIT_C157711 @default.
- NCIT_C189085 inSubset NCIT_C157712 @default.
- NCIT_C189085 inSubset NCIT_C176424 @default.
- NCIT_C189085 type Class @default.
- NCIT_C189085 isDefinedBy ncit.owl @default.
- NCIT_C189085 label "EGFR Mutant-selective Inhibitor HS-10375" @default.
- NCIT_C189085 subClassOf NCIT_C129824 @default.
- NCIT_C189085 subClassOf NCIT_C129825 @default.
- NCIT_C189085 subClassOf NCIT_C1404 @default.
- NCIT_C189085 subClassOf NCIT_C163758 @default.
- NCIT_C189085 subClassOf NCIT_C163952 @default.
- NCIT_C189085 subClassOf NCIT_C189085 @default.
- NCIT_C189085 subClassOf NCIT_C1908 @default.
- NCIT_C189085 subClassOf NCIT_C1909 @default.
- NCIT_C189085 subClassOf NCIT_C1967 @default.
- NCIT_C189085 subClassOf NCIT_C2167 @default.
- NCIT_C189085 subClassOf NCIT_C2189 @default.
- NCIT_C189085 subClassOf NCIT_C274 @default.
- NCIT_C189085 subClassOf NCIT_C471 @default.