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- NCIT_C18909 IAO_0000115 "Any DNA sequence alteration process occurring in a proto-oncogene, resulting in loss of regulation of the gene product, and predisposing the cell to neoplastic transformation. Proto-oncogenes are ordinarilly involved in transduction of signals that regulate cell growth and differentiation. Activation of such genes overrides the normal mechanisms of regulation and is an important step in the process of cellular transformation." @default.
- NCIT_C18909 NCIT_NHC0 "C18909" @default.
- NCIT_C18909 NCIT_P106 "Cell or Molecular Dysfunction" @default.
- NCIT_C18909 NCIT_P108 "Oncogene Activation Process" @default.
- NCIT_C18909 NCIT_P207 "C1518575" @default.
- NCIT_C18909 NCIT_P366 "Oncogene_Activation" @default.
- NCIT_C18909 NCIT_P98 "Gain of function mutations in proto-oncogenes generally act in a dominant fashion, meaning that only a single copy of the DNA sequence alteration is necessary for the step along the path to transformation." @default.
- NCIT_C18909 NCIT_R35 NCIT_C16956 @default.
- NCIT_C18909 NCIT_R35 NCIT_C17828 @default.
- NCIT_C18909 NCIT_R35 NCIT_C18121 @default.
- NCIT_C18909 NCIT_R35 NCIT_C18264 @default.
- NCIT_C18909 NCIT_R35 NCIT_C21188 @default.
- NCIT_C18909 normalizedInformationContent "100" @default.
- NCIT_C18909 referenceCount "1" @default.
- NCIT_C18909 hasExactSynonym "Oncogene Activation Process" @default.
- NCIT_C18909 hasExactSynonym "Oncogene Activation" @default.
- NCIT_C18909 type Class @default.
- NCIT_C18909 isDefinedBy ncit.owl @default.
- NCIT_C18909 label "Oncogene Activation Process" @default.
- NCIT_C18909 subClassOf B5b69858c10ea0fcffe2fb3a34b801490 @default.
- NCIT_C18909 subClassOf Bd80580b2fb0f42493bb973ce38f28a7d @default.
- NCIT_C18909 subClassOf NCIT_C17710 @default.
- NCIT_C18909 subClassOf NCIT_C17828 @default.
- NCIT_C18909 subClassOf NCIT_C18909 @default.
- NCIT_C18909 subClassOf NCIT_C19152 @default.
- NCIT_C18909 subClassOf NCIT_C21068 @default.
- NCIT_C18909 subClassOf NCIT_C28498 @default.