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- NCIT_C189091 IAO_0000115 "An orally bioavailable, mutant-selective, dual kinase inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with potential antineoplastic activity. Upon oral administration, EGFR/HER2 mutant-selective inhibitor HS-10376 targets, binds to, and inhibits the activity of EGFR and HER2 with exon20 insertion mutations, thereby preventing EGFR- and HER2-mediated signaling. This may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization." @default.
- NCIT_C189091 NCIT_A7 NCIT_C125605 @default.
- NCIT_C189091 NCIT_A7 NCIT_C150633 @default.
- NCIT_C189091 NCIT_NHC0 "C189091" @default.
- NCIT_C189091 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189091 NCIT_P108 "EGFR/HER2 Mutant-selective Inhibitor HS-10376" @default.
- NCIT_C189091 NCIT_P208 "CL1794293" @default.
- NCIT_C189091 NCIT_P322 "GDC" @default.
- NCIT_C189091 NCIT_P399 "810256" @default.
- NCIT_C189091 normalizedInformationContent "100" @default.
- NCIT_C189091 referenceCount "1" @default.
- NCIT_C189091 hasExactSynonym "EGFR/HER2 Exon 20 Inhibitor HS-10376" @default.
- NCIT_C189091 hasExactSynonym "EGFR/HER2 Mutant-selective Inhibitor HS-10376" @default.
- NCIT_C189091 hasExactSynonym "HS 10376" @default.
- NCIT_C189091 hasExactSynonym "HS-10376" @default.
- NCIT_C189091 hasExactSynonym "HS10376" @default.
- NCIT_C189091 inSubset NCIT_C128784 @default.
- NCIT_C189091 inSubset NCIT_C157711 @default.
- NCIT_C189091 inSubset NCIT_C157712 @default.
- NCIT_C189091 inSubset NCIT_C176424 @default.
- NCIT_C189091 type Class @default.
- NCIT_C189091 isDefinedBy ncit.owl @default.
- NCIT_C189091 label "EGFR/HER2 Mutant-selective Inhibitor HS-10376" @default.
- NCIT_C189091 subClassOf NCIT_C129824 @default.
- NCIT_C189091 subClassOf NCIT_C129825 @default.
- NCIT_C189091 subClassOf NCIT_C1404 @default.
- NCIT_C189091 subClassOf NCIT_C159156 @default.
- NCIT_C189091 subClassOf NCIT_C163758 @default.
- NCIT_C189091 subClassOf NCIT_C163760 @default.
- NCIT_C189091 subClassOf NCIT_C163952 @default.
- NCIT_C189091 subClassOf NCIT_C189091 @default.
- NCIT_C189091 subClassOf NCIT_C1908 @default.
- NCIT_C189091 subClassOf NCIT_C1909 @default.
- NCIT_C189091 subClassOf NCIT_C1967 @default.
- NCIT_C189091 subClassOf NCIT_C199379 @default.
- NCIT_C189091 subClassOf NCIT_C2167 @default.
- NCIT_C189091 subClassOf NCIT_C2189 @default.
- NCIT_C189091 subClassOf NCIT_C274 @default.
- NCIT_C189091 subClassOf NCIT_C471 @default.