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- NCIT_C189093 IAO_0000115 "A preparation of tumor-infiltrating lymphocytes (TILs) that have been genetically engineered to express membrane-bound IL-15 (mbIL15), with potential immunostimulating and antineoplastic activities. Upon introduction of the mbIL15-expressing TILs OBX-115, the TILs target and kill tumor cells. IL-15 is a pro-survival cytokine that is required for the maintenance of long-lived CD8+ memory T-cells. Sustained IL-15 signaling enhances TIL persistence and potency compared to un-engineered TILs. OBX-115 may replace the need for concomitant administration of systemic IL-2 which is needed to improve the efficacy of conventional TILs." @default.
- NCIT_C189093 NCIT_NHC0 "C189093" @default.
- NCIT_C189093 NCIT_P106 "Cell" @default.
- NCIT_C189093 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189093 NCIT_P107 "Membrane-bound IL-15-expressing Tumor-infiltrating Lymphocytes OBX-115" @default.
- NCIT_C189093 NCIT_P108 "Membrane-bound IL-15-expressing Tumor-infiltrating Lymphocytes OBX-115" @default.
- NCIT_C189093 NCIT_P208 "CL1794286" @default.
- NCIT_C189093 NCIT_P322 "CTRP" @default.
- NCIT_C189093 NCIT_P399 "810459" @default.
- NCIT_C189093 normalizedInformationContent "100" @default.
- NCIT_C189093 referenceCount "1" @default.
- NCIT_C189093 hasExactSynonym "CytoTIL15" @default.
- NCIT_C189093 hasExactSynonym "IL-15-engineered TILs OBX-115" @default.
- NCIT_C189093 hasExactSynonym "IL-15-engineered tumor-infiltrating lymphocytes OBX-115" @default.
- NCIT_C189093 hasExactSynonym "IL15-engineered TILs OBX-115" @default.
- NCIT_C189093 hasExactSynonym "Membrane-bound IL-15-expressing Tumor-infiltrating Lymphocytes OBX-115" @default.
- NCIT_C189093 hasExactSynonym "OBX 115" @default.
- NCIT_C189093 hasExactSynonym "OBX-115" @default.
- NCIT_C189093 hasExactSynonym "OBX115" @default.
- NCIT_C189093 hasExactSynonym "bIL15-expressing TILs OBX-115" @default.
- NCIT_C189093 inSubset NCIT_C116977 @default.
- NCIT_C189093 inSubset NCIT_C116978 @default.
- NCIT_C189093 inSubset NCIT_C128784 @default.
- NCIT_C189093 inSubset NCIT_C176424 @default.
- NCIT_C189093 type Class @default.
- NCIT_C189093 isDefinedBy ncit.owl @default.
- NCIT_C189093 label "Membrane-bound IL-15-expressing Tumor-infiltrating Lymphocytes OBX-115" @default.
- NCIT_C189093 subClassOf NCIT_C129820 @default.
- NCIT_C189093 subClassOf NCIT_C129821 @default.
- NCIT_C189093 subClassOf NCIT_C129826 @default.
- NCIT_C189093 subClassOf NCIT_C142078 @default.
- NCIT_C189093 subClassOf NCIT_C154231 @default.
- NCIT_C189093 subClassOf NCIT_C189093 @default.
- NCIT_C189093 subClassOf NCIT_C1908 @default.
- NCIT_C189093 subClassOf NCIT_C1909 @default.
- NCIT_C189093 subClassOf NCIT_C1962 @default.
- NCIT_C189093 subClassOf NCIT_C201547 @default.
- NCIT_C189093 subClassOf NCIT_C274 @default.
- NCIT_C189093 subClassOf NCIT_C307 @default.
- NCIT_C189093 subClassOf NCIT_C308 @default.