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- NCIT_C189702 IAO_0000115 "A preparation of allogeneic T-lymphocytes that have been transduced with a bivalent lentiviral vector encoding a chimeric antigen receptor (CAR) targeting the two tumor-associated antigens (TAAs) CD19 and CD22, linked to the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-CD19/CD22 CAR-BBz T-cells bind to and induce selective toxicity in tumor cells expressing CD19 and CD22. CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are often overexpressed on malignant B-cells. By simultaneously targeting two B-cell antigens, this preparation may minimize relapse due to single antigen loss in patients with B-cell malignancies." @default.
- NCIT_C189702 NCIT_A7 NCIT_C17279 @default.
- NCIT_C189702 NCIT_A7 NCIT_C38894 @default.
- NCIT_C189702 NCIT_NHC0 "C189702" @default.
- NCIT_C189702 NCIT_P106 "Cell" @default.
- NCIT_C189702 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189702 NCIT_P107 "Allogeneic Anti-CD19/CD22 CAR-BBz T-cells" @default.
- NCIT_C189702 NCIT_P108 "Allogeneic Anti-CD19/CD22 CAR-BBz T-cells" @default.
- NCIT_C189702 NCIT_P208 "CL1798441" @default.
- NCIT_C189702 NCIT_P322 "CTRP" @default.
- NCIT_C189702 NCIT_P322 "GDC" @default.
- NCIT_C189702 NCIT_P399 "810690" @default.
- NCIT_C189702 normalizedInformationContent "100" @default.
- NCIT_C189702 referenceCount "1" @default.
- NCIT_C189702 hasExactSynonym "Allogeneic Anti-CD19/Anti-CD22 CAR T Cells" @default.
- NCIT_C189702 hasExactSynonym "Allogeneic Anti-CD19/CD22 CAR T-cells" @default.
- NCIT_C189702 hasExactSynonym "Allogeneic Anti-CD19/CD22 CAR-BBz T-cells" @default.
- NCIT_C189702 hasExactSynonym "Allogeneic Anti-CD19/CD22 CAR-T Cells" @default.
- NCIT_C189702 hasExactSynonym "Allogeneic CD19/CD22-BBz CAR T Cells" @default.
- NCIT_C189702 hasExactSynonym "Allogeneic CD19/CD22-CAR T Cells" @default.
- NCIT_C189702 inSubset NCIT_C116977 @default.
- NCIT_C189702 inSubset NCIT_C116978 @default.
- NCIT_C189702 inSubset NCIT_C128784 @default.
- NCIT_C189702 inSubset NCIT_C157711 @default.
- NCIT_C189702 inSubset NCIT_C157712 @default.
- NCIT_C189702 inSubset NCIT_C176424 @default.
- NCIT_C189702 type Class @default.
- NCIT_C189702 isDefinedBy ncit.owl @default.
- NCIT_C189702 label "Allogeneic Anti-CD19/CD22 CAR-BBz T-cells" @default.
- NCIT_C189702 subClassOf NCIT_C129820 @default.
- NCIT_C189702 subClassOf NCIT_C129821 @default.
- NCIT_C189702 subClassOf NCIT_C129826 @default.
- NCIT_C189702 subClassOf NCIT_C137999 @default.
- NCIT_C189702 subClassOf NCIT_C142078 @default.
- NCIT_C189702 subClassOf NCIT_C154231 @default.
- NCIT_C189702 subClassOf NCIT_C176018 @default.
- NCIT_C189702 subClassOf NCIT_C189702 @default.
- NCIT_C189702 subClassOf NCIT_C1908 @default.
- NCIT_C189702 subClassOf NCIT_C1909 @default.
- NCIT_C189702 subClassOf NCIT_C1962 @default.
- NCIT_C189702 subClassOf NCIT_C200765 @default.
- NCIT_C189702 subClassOf NCIT_C201173 @default.
- NCIT_C189702 subClassOf NCIT_C274 @default.
- NCIT_C189702 subClassOf NCIT_C28676 @default.
- NCIT_C189702 subClassOf NCIT_C307 @default.
- NCIT_C189702 subClassOf NCIT_C308 @default.