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- NCIT_C189802 IAO_0000115 "The maleate salt form of sutetinib, an orally bioavailable, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration, sutetinib selectively targets, irreversibly binds to, and inhibits the activity of various EGFR mutations, including the less common mutations L861Q, G719X, and S768I. This prevents EGFR-mediated signaling in susceptible tumor cells. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and survival." @default.
- NCIT_C189802 NCIT_A7 NCIT_C17068 @default.
- NCIT_C189802 NCIT_NHC0 "C189802" @default.
- NCIT_C189802 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189802 NCIT_P107 "Sutetinib Maleate" @default.
- NCIT_C189802 NCIT_P108 "Sutetinib Maleate" @default.
- NCIT_C189802 NCIT_P208 "CL1798632" @default.
- NCIT_C189802 NCIT_P210 "1701408-75-4" @default.
- NCIT_C189802 NCIT_P319 "KEV8HMY439" @default.
- NCIT_C189802 NCIT_P322 "CTRP" @default.
- NCIT_C189802 NCIT_P322 "FDA" @default.
- NCIT_C189802 NCIT_P322 "GDC" @default.
- NCIT_C189802 normalizedInformationContent "100" @default.
- NCIT_C189802 referenceCount "1" @default.
- NCIT_C189802 hasExactSynonym "SUTETINIB MALEATE" @default.
- NCIT_C189802 hasExactSynonym "Sutetinib Maleate" @default.
- NCIT_C189802 inSubset NCIT_C116977 @default.
- NCIT_C189802 inSubset NCIT_C116978 @default.
- NCIT_C189802 inSubset NCIT_C128784 @default.
- NCIT_C189802 inSubset NCIT_C157711 @default.
- NCIT_C189802 inSubset NCIT_C157712 @default.
- NCIT_C189802 inSubset NCIT_C176424 @default.
- NCIT_C189802 inSubset NCIT_C63923 @default.
- NCIT_C189802 type Class @default.
- NCIT_C189802 isDefinedBy ncit.owl @default.
- NCIT_C189802 label "Sutetinib Maleate" @default.
- NCIT_C189802 subClassOf NCIT_C129824 @default.
- NCIT_C189802 subClassOf NCIT_C129825 @default.
- NCIT_C189802 subClassOf NCIT_C1404 @default.
- NCIT_C189802 subClassOf NCIT_C163758 @default.
- NCIT_C189802 subClassOf NCIT_C163952 @default.
- NCIT_C189802 subClassOf NCIT_C189802 @default.
- NCIT_C189802 subClassOf NCIT_C1908 @default.
- NCIT_C189802 subClassOf NCIT_C1909 @default.
- NCIT_C189802 subClassOf NCIT_C1967 @default.
- NCIT_C189802 subClassOf NCIT_C2167 @default.
- NCIT_C189802 subClassOf NCIT_C2189 @default.
- NCIT_C189802 subClassOf NCIT_C274 @default.
- NCIT_C189802 subClassOf NCIT_C471 @default.