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- NCIT_C189806 IAO_0000115 "A bivalent booster vaccine consisting of tozinameran, lipid nanoparticle (LNP) encapsulating a nucleoside modified messenger RNA (modRNA) encoding an optimized form of the full-length viral spike (S) glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Wuhan-Hu-1 strain (Original), and riltozinameran, a LNP encapsulating a modRNA encoding an optimized form of the full-length viral S protein of the SARS-CoV-2 Omicron variant B.1.1.529, with potential immunizing and anti-COVID-19 activities. Upon injection of riltozinameran/tozinameran, the LNPs bind to the plasma membrane of nearby cells and release SARS-CoV-2 S protein mRNA into the cells. The mRNA is then translated by the cellular protein translation machinery to produce SARS-CoV-2 S protein. This may activate both humoral and cellular immune responses which may result in protection against SARS-CoV-2 infection." @default.
- NCIT_C189806 NCIT_NHC0 "C189806" @default.
- NCIT_C189806 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189806 NCIT_P108 "Riltozinameran/Tozinameran" @default.
- NCIT_C189806 NCIT_P208 "CL1798635" @default.
- NCIT_C189806 normalizedInformationContent "100" @default.
- NCIT_C189806 referenceCount "1" @default.
- NCIT_C189806 hasExactSynonym "Comirnaty Original/Omicron BA.1" @default.
- NCIT_C189806 hasExactSynonym "Riltozinameran/Tozinameran" @default.
- NCIT_C189806 inSubset NCIT_C173381 @default.
- NCIT_C189806 inSubset NCIT_C173383 @default.
- NCIT_C189806 type Class @default.
- NCIT_C189806 isDefinedBy ncit.owl @default.
- NCIT_C189806 label "Riltozinameran/Tozinameran" @default.
- NCIT_C189806 subClassOf NCIT_C172787 @default.
- NCIT_C189806 subClassOf NCIT_C173023 @default.
- NCIT_C189806 subClassOf NCIT_C181140 @default.
- NCIT_C189806 subClassOf NCIT_C189806 @default.
- NCIT_C189806 subClassOf NCIT_C1908 @default.
- NCIT_C189806 subClassOf NCIT_C1909 @default.
- NCIT_C189806 subClassOf NCIT_C307 @default.
- NCIT_C189806 subClassOf NCIT_C308 @default.
- NCIT_C189806 subClassOf NCIT_C923 @default.