Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C189813> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- NCIT_C189813 IAO_0000115 "A bispecific antibody fusion protein composed of a monoclonal antibody targeting the negative immunoregulatory human cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and fused to a mutated form of the endogenous cytokine interleukin-2 (IL-2), with potential immunostimulating and antineoplastic activities. Upon administration, anti-PD-1/IL-2 bispecific antibody fusion protein IBI363 targets and binds to PD-1 expressed on PD-1-expressing T-cells, thereby inhibiting PD-1-mediated signaling. This may restore immune function through the activation of T-cells and T-cell-mediated immune responses against tumor cells. IL-2 targets and binds to the IL-2 receptor IL2R and activates IL-2/IL-2R-mediated signaling, which further activates cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells, and induces expression of certain cytotoxic cytokines, such as interferon-gamma (IFNg) and transforming growth factor-beta (TGFb). This further enhances T-cell-mediated cytotoxic immune responses against tumor cells. By selectively activating PD-1 positive T-cells by IL-2, but not PD-1 negative bystander or naïve T cells, the activity of tumor specific T-cells is specifically enhanced while IL-2-induced systemic toxicity is decreased. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274) or 2 (PD-L2); it plays an important role in tumor evasion from host immunity." @default.
- NCIT_C189813 NCIT_A7 NCIT_C94697 @default.
- NCIT_C189813 NCIT_NHC0 "C189813" @default.
- NCIT_C189813 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C189813 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C189813 NCIT_P108 "Anti-PD-1/IL-2 Bispecific Antibody Fusion Protein IBI363" @default.
- NCIT_C189813 NCIT_P208 "CL1798640" @default.
- NCIT_C189813 NCIT_P322 "GDC" @default.
- NCIT_C189813 NCIT_P399 "810340" @default.
- NCIT_C189813 NCIT_R124 NCIT_C17828 @default.
- NCIT_C189813 NCIT_R124 NCIT_C18992 @default.
- NCIT_C189813 NCIT_R124 NCIT_C19143 @default.
- NCIT_C189813 NCIT_R124 NCIT_C21124 @default.
- NCIT_C189813 NCIT_R124 NCIT_C40702 @default.
- NCIT_C189813 NCIT_R124 NCIT_C45547 @default.
- NCIT_C189813 NCIT_R125 NCIT_C16395 @default.
- NCIT_C189813 NCIT_R125 NCIT_C17710 @default.
- NCIT_C189813 NCIT_R125 NCIT_C17828 @default.
- NCIT_C189813 NCIT_R125 NCIT_C17937 @default.
- NCIT_C189813 NCIT_R125 NCIT_C18081 @default.
- NCIT_C189813 NCIT_R125 NCIT_C18095 @default.
- NCIT_C189813 NCIT_R125 NCIT_C18839 @default.
- NCIT_C189813 NCIT_R125 NCIT_C20480 @default.
- NCIT_C189813 NCIT_R125 NCIT_C20751 @default.
- NCIT_C189813 NCIT_R125 NCIT_C21049 @default.
- NCIT_C189813 NCIT_R125 NCIT_C21050 @default.
- NCIT_C189813 NCIT_R125 NCIT_C21124 @default.
- NCIT_C189813 NCIT_R125 NCIT_C26280 @default.
- NCIT_C189813 NCIT_R125 NCIT_C28498 @default.
- NCIT_C189813 NCIT_R125 NCIT_C40767 @default.
- NCIT_C189813 NCIT_R125 NCIT_C40833 @default.
- NCIT_C189813 NCIT_R125 NCIT_C40912 @default.
- NCIT_C189813 NCIT_R146 NCIT_C104679 @default.
- NCIT_C189813 NCIT_R146 NCIT_C21176 @default.
- NCIT_C189813 NCIT_R146 NCIT_C26548 @default.
- NCIT_C189813 normalizedInformationContent "100" @default.
- NCIT_C189813 referenceCount "1" @default.
- NCIT_C189813 hasExactSynonym "Anti-PD-1/IL-2 Bispecific Antibody Fusion Protein IBI363" @default.
- NCIT_C189813 hasExactSynonym "Anti-PD-1/IL-2 Bispecific Fusion Protein IBI363" @default.
- NCIT_C189813 hasExactSynonym "Fusion Protein IBI363" @default.
- NCIT_C189813 hasExactSynonym "IBI 363" @default.
- NCIT_C189813 hasExactSynonym "IBI-363" @default.
- NCIT_C189813 hasExactSynonym "IBI363" @default.
- NCIT_C189813 hasExactSynonym "PD-1/IL-2 Bispecific Molecule IBI363" @default.
- NCIT_C189813 inSubset NCIT_C128784 @default.
- NCIT_C189813 inSubset NCIT_C157711 @default.
- NCIT_C189813 inSubset NCIT_C157712 @default.
- NCIT_C189813 inSubset NCIT_C176424 @default.
- NCIT_C189813 type Class @default.
- NCIT_C189813 isDefinedBy ncit.owl @default.
- NCIT_C189813 label "Anti-PD-1/IL-2 Bispecific Antibody Fusion Protein IBI363" @default.
- NCIT_C189813 subClassOf NCIT_C1283 @default.
- NCIT_C189813 subClassOf NCIT_C189813 @default.
- NCIT_C189813 subClassOf NCIT_C1908 @default.
- NCIT_C189813 subClassOf NCIT_C1909 @default.
- NCIT_C189813 subClassOf NCIT_C307 @default.
- NCIT_C189813 subClassOf NCIT_C308 @default.
- NCIT_C189813 subClassOf NCIT_C587 @default.
- NCIT_C189813 subClassOf NCIT_C593 @default.