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- NCIT_C189815 IAO_0000115 "An orally bioavailable inhibitor of the nuclear export protein exportin-1 (XPO1; chromosome region maintenance 1 protein homolog; CRM1), with potential antineoplastic and pro-apoptotic activities. Upon administration, XPO1 inhibitor WJ01075 targets and binds to XPO1, and prevents the XPO1-mediated nuclear export of cargo proteins, including tumor suppressor proteins (TSPs), such as p53, FOXO, p21, and p27. This leads to their selective accumulation in the nuclei of tumor cells, which restores the nuclear localization and function of TSPs, and induces apoptosis in tumor cells. XPO1, the major export factor that transports proteins and RNA from the nucleus to the cytoplasm, is overexpressed in a variety of cancer cell types while minimally expressed in normal, healthy cells. The dysregulated export of TSPs into the cytoplasm prevents TSP-initiated apoptosis. XPO1 overexpression leads to uncontrolled tumor cell proliferation and is associated with poor prognosis." @default.
- NCIT_C189815 NCIT_A7 NCIT_C99488 @default.
- NCIT_C189815 NCIT_NHC0 "C189815" @default.
- NCIT_C189815 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189815 NCIT_P108 "XPO1 Inhibitor WJ01075" @default.
- NCIT_C189815 NCIT_P208 "CL1798642" @default.
- NCIT_C189815 NCIT_P322 "GDC" @default.
- NCIT_C189815 NCIT_P399 "810348" @default.
- NCIT_C189815 normalizedInformationContent "100" @default.
- NCIT_C189815 referenceCount "1" @default.
- NCIT_C189815 hasExactSynonym "W J 01075" @default.
- NCIT_C189815 hasExactSynonym "W-J 01075" @default.
- NCIT_C189815 hasExactSynonym "WJ 01075" @default.
- NCIT_C189815 hasExactSynonym "XPO1 Inhibitor WJ01075" @default.
- NCIT_C189815 inSubset NCIT_C128784 @default.
- NCIT_C189815 inSubset NCIT_C157711 @default.
- NCIT_C189815 inSubset NCIT_C157712 @default.
- NCIT_C189815 inSubset NCIT_C176424 @default.
- NCIT_C189815 type Class @default.
- NCIT_C189815 isDefinedBy ncit.owl @default.
- NCIT_C189815 label "XPO1 Inhibitor WJ01075" @default.
- NCIT_C189815 subClassOf NCIT_C129824 @default.
- NCIT_C189815 subClassOf NCIT_C189815 @default.
- NCIT_C189815 subClassOf NCIT_C1908 @default.
- NCIT_C189815 subClassOf NCIT_C1909 @default.
- NCIT_C189815 subClassOf NCIT_C198515 @default.
- NCIT_C189815 subClassOf NCIT_C2189 @default.
- NCIT_C189815 subClassOf NCIT_C274 @default.