Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C189819> ?p ?o ?g. }
Showing items 1 to 40 of
40
with 100 items per page.
- NCIT_C189819 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the tumor-associated antigen (TAA) carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5; CEA), linked to an undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration of anti-CEACAM5 ADC M9140, the anti-CEACAM5 monoclonal antibody moiety targets and binds to CEACAM5 expressed on tumor cells. Upon binding and internalization, the cytotoxic agent is released and kills CEACAM5-expressing tumor cells through an as of yet undisclosed mechanism. CEACAM5, a member of the CEA family of proteins that plays a key role in cell migration, cell invasion, and cell adhesion, is overexpressed by a variety of cancer cell types." @default.
- NCIT_C189819 NCIT_A7 NCIT_C16384 @default.
- NCIT_C189819 NCIT_NHC0 "C189819" @default.
- NCIT_C189819 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189819 NCIT_P107 "Anti-CEACAM5 Antibody-drug Conjugate M9140" @default.
- NCIT_C189819 NCIT_P108 "Anti-CEACAM5 Antibody-drug Conjugate M9140" @default.
- NCIT_C189819 NCIT_P208 "CL1798646" @default.
- NCIT_C189819 NCIT_P322 "CTRP" @default.
- NCIT_C189819 NCIT_P322 "GDC" @default.
- NCIT_C189819 NCIT_P399 "810384" @default.
- NCIT_C189819 normalizedInformationContent "100" @default.
- NCIT_C189819 referenceCount "1" @default.
- NCIT_C189819 hasExactSynonym "Anti-CEA ADC M9140" @default.
- NCIT_C189819 hasExactSynonym "Anti-CEA Antibody-drug Conjugate M9140" @default.
- NCIT_C189819 hasExactSynonym "Anti-CEACAM5 ADC M9140" @default.
- NCIT_C189819 hasExactSynonym "Anti-CEACAM5 Antibody-drug Conjugate M9140" @default.
- NCIT_C189819 hasExactSynonym "M 9140" @default.
- NCIT_C189819 hasExactSynonym "M-9140" @default.
- NCIT_C189819 hasExactSynonym "M9140" @default.
- NCIT_C189819 inSubset NCIT_C116977 @default.
- NCIT_C189819 inSubset NCIT_C116978 @default.
- NCIT_C189819 inSubset NCIT_C128784 @default.
- NCIT_C189819 inSubset NCIT_C157711 @default.
- NCIT_C189819 inSubset NCIT_C157712 @default.
- NCIT_C189819 inSubset NCIT_C176424 @default.
- NCIT_C189819 type Class @default.
- NCIT_C189819 isDefinedBy ncit.owl @default.
- NCIT_C189819 label "Anti-CEACAM5 Antibody-drug Conjugate M9140" @default.
- NCIT_C189819 subClassOf NCIT_C129821 @default.
- NCIT_C189819 subClassOf NCIT_C129823 @default.
- NCIT_C189819 subClassOf NCIT_C1512 @default.
- NCIT_C189819 subClassOf NCIT_C163758 @default.
- NCIT_C189819 subClassOf NCIT_C189819 @default.
- NCIT_C189819 subClassOf NCIT_C1908 @default.
- NCIT_C189819 subClassOf NCIT_C1909 @default.
- NCIT_C189819 subClassOf NCIT_C200043 @default.
- NCIT_C189819 subClassOf NCIT_C201549 @default.
- NCIT_C189819 subClassOf NCIT_C274 @default.
- NCIT_C189819 subClassOf NCIT_C307 @default.
- NCIT_C189819 subClassOf NCIT_C308 @default.