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- NCIT_C189822 IAO_0000115 "A bispecific antibody directed against both the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) and the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-DLL3/CD3 bispecific antibody QLS31904 binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and the DLL3 antigen on DLL3-expressing tumor cells. This activates and redirects CTLs to DLL3-expressing tumor cells, which results in the CTL-mediated cell death of DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation." @default.
- NCIT_C189822 NCIT_A7 NCIT_C104256 @default.
- NCIT_C189822 NCIT_NHC0 "C189822" @default.
- NCIT_C189822 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189822 NCIT_P108 "Anti-DLL3/CD3 Bispecific Antibody QLS31904" @default.
- NCIT_C189822 NCIT_P208 "CL1798651" @default.
- NCIT_C189822 NCIT_P322 "GDC" @default.
- NCIT_C189822 NCIT_P399 "810365" @default.
- NCIT_C189822 NCIT_R124 NCIT_C17710 @default.
- NCIT_C189822 NCIT_R124 NCIT_C17828 @default.
- NCIT_C189822 NCIT_R124 NCIT_C18219 @default.
- NCIT_C189822 NCIT_R124 NCIT_C19986 @default.
- NCIT_C189822 NCIT_R124 NCIT_C40474 @default.
- NCIT_C189822 normalizedInformationContent "100" @default.
- NCIT_C189822 referenceCount "1" @default.
- NCIT_C189822 hasExactSynonym "Anti-DLL3/Anti-CD3 Bispecific Antibody QLS31904" @default.
- NCIT_C189822 hasExactSynonym "Anti-DLL3/CD3 Bispecific Antibody QLS31904" @default.
- NCIT_C189822 hasExactSynonym "DLL3 x CD3 Bispecific Antibody QLS31904" @default.
- NCIT_C189822 hasExactSynonym "QLS 31904" @default.
- NCIT_C189822 hasExactSynonym "QLS-31904" @default.
- NCIT_C189822 hasExactSynonym "QLS31904" @default.
- NCIT_C189822 inSubset NCIT_C128784 @default.
- NCIT_C189822 inSubset NCIT_C157711 @default.
- NCIT_C189822 inSubset NCIT_C157712 @default.
- NCIT_C189822 inSubset NCIT_C176424 @default.
- NCIT_C189822 type Class @default.
- NCIT_C189822 isDefinedBy ncit.owl @default.
- NCIT_C189822 label "Anti-DLL3/CD3 Bispecific Antibody QLS31904" @default.
- NCIT_C189822 subClassOf NCIT_C112883 @default.
- NCIT_C189822 subClassOf NCIT_C129821 @default.
- NCIT_C189822 subClassOf NCIT_C129822 @default.
- NCIT_C189822 subClassOf NCIT_C1454 @default.
- NCIT_C189822 subClassOf NCIT_C163758 @default.
- NCIT_C189822 subClassOf NCIT_C189822 @default.
- NCIT_C189822 subClassOf NCIT_C1908 @default.
- NCIT_C189822 subClassOf NCIT_C1909 @default.
- NCIT_C189822 subClassOf NCIT_C200611 @default.
- NCIT_C189822 subClassOf NCIT_C200615 @default.
- NCIT_C189822 subClassOf NCIT_C201282 @default.
- NCIT_C189822 subClassOf NCIT_C20401 @default.
- NCIT_C189822 subClassOf NCIT_C274 @default.
- NCIT_C189822 subClassOf NCIT_C28227 @default.
- NCIT_C189822 subClassOf NCIT_C307 @default.
- NCIT_C189822 subClassOf NCIT_C308 @default.