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- NCIT_C189823 IAO_0000115 "A small molecule, chaperone-mediated protein degrader of bromodomain-containing protein 4 (BRD4), with potential antineoplastic activity. Upon intravenous administration of BRD4 protein degrader RNK05047, a BRD4-binding moiety targets and binds to BRD4, and a chaperone-binding moiety targets and binds to the chaperone protein heat shock protein 90 (Hsp90). This results in the Hsp90-mediated proteasomal degradation of BRD4 by the ubiquitin-proteasome system, and dysregulates gene expression. This may lead to the downregulation of the expression of certain growth-promoting genes, which may induce apoptosis and inhibit the proliferation of BRD4-overexpressing tumor cells. BRD4, a member of the human bromodomain and extra-terminal (BET) family of proteins, is a transcriptional regulator that is overexpressed in certain tumor cells and plays an important role in cellular proliferation. Hsp90 is upregulated in a variety of tumor cells and regulates the folding, stability, and degradation of many oncogenic signaling proteins." @default.
- NCIT_C189823 NCIT_A7 NCIT_C92704 @default.
- NCIT_C189823 NCIT_NHC0 "C189823" @default.
- NCIT_C189823 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189823 NCIT_P107 "BRD4 Protein Degrader RNK05047" @default.
- NCIT_C189823 NCIT_P108 "BRD4 Protein Degrader RNK05047" @default.
- NCIT_C189823 NCIT_P208 "CL1798650" @default.
- NCIT_C189823 NCIT_P322 "CTRP" @default.
- NCIT_C189823 NCIT_P322 "GDC" @default.
- NCIT_C189823 NCIT_P399 "810364" @default.
- NCIT_C189823 normalizedInformationContent "100" @default.
- NCIT_C189823 referenceCount "1" @default.
- NCIT_C189823 hasExactSynonym "BRD4 Degrader RNK05047" @default.
- NCIT_C189823 hasExactSynonym "BRD4 Protein Degrader RNK05047" @default.
- NCIT_C189823 hasExactSynonym "BRD4-targeting CHAMP Protein Degrader RNK05047" @default.
- NCIT_C189823 hasExactSynonym "BRD4-targeting Protein Degrader RNK05047" @default.
- NCIT_C189823 hasExactSynonym "RNK 05047" @default.
- NCIT_C189823 hasExactSynonym "RNK-05047" @default.
- NCIT_C189823 hasExactSynonym "RNK05047" @default.
- NCIT_C189823 inSubset NCIT_C116977 @default.
- NCIT_C189823 inSubset NCIT_C116978 @default.
- NCIT_C189823 inSubset NCIT_C128784 @default.
- NCIT_C189823 inSubset NCIT_C157711 @default.
- NCIT_C189823 inSubset NCIT_C157712 @default.
- NCIT_C189823 inSubset NCIT_C176424 @default.
- NCIT_C189823 type Class @default.
- NCIT_C189823 isDefinedBy ncit.owl @default.
- NCIT_C189823 label "BRD4 Protein Degrader RNK05047" @default.
- NCIT_C189823 subClassOf NCIT_C128462 @default.
- NCIT_C189823 subClassOf NCIT_C129824 @default.
- NCIT_C189823 subClassOf NCIT_C189823 @default.
- NCIT_C189823 subClassOf NCIT_C1908 @default.
- NCIT_C189823 subClassOf NCIT_C1909 @default.
- NCIT_C189823 subClassOf NCIT_C2189 @default.
- NCIT_C189823 subClassOf NCIT_C274 @default.