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- NCIT_C189826 IAO_0000115 "A peptide-drug conjugate (PDC) of paclitaxel with an inhibitor of CXC chemokine receptor 4 (CXCR4), with potential antineoplastic activity. Upon administration of paclitaxel-conjugated CXCR4 peptide antagonist MB1707, the CXCR4 inhibitor moiety binds to the chemokine receptor CXCR4 expressed on tumor cells, thereby preventing CXCR4 binding to its ligand, stromal derived factor-1 (SDF-1), and subsequent receptor activation. This may result in decreased tumor cell proliferation and migration. In addition, paclitaxel binds to tubulin inside CXCR4-expressing tumor cells and inhibits the disassembly-assembly dynamics of microtubules, resulting in cell cycle arrest and cell death. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types. By targeting CXCR4-expressing tumor cells specifically, paclitaxel's efficacy is increased while minimizing systemic toxiciy." @default.
- NCIT_C189826 NCIT_A7 NCIT_C17789 @default.
- NCIT_C189826 NCIT_NHC0 "C189826" @default.
- NCIT_C189826 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189826 NCIT_P108 "Paclitaxel-conjugated CXCR4 Peptide Antagonist MB1707" @default.
- NCIT_C189826 NCIT_P208 "CL1798596" @default.
- NCIT_C189826 NCIT_P322 "GDC" @default.
- NCIT_C189826 NCIT_P399 "810387" @default.
- NCIT_C189826 NCIT_R124 NCIT_C17828 @default.
- NCIT_C189826 NCIT_R124 NCIT_C20480 @default.
- NCIT_C189826 NCIT_R124 NCIT_C40795 @default.
- NCIT_C189826 NCIT_R124 NCIT_C40798 @default.
- NCIT_C189826 normalizedInformationContent "100" @default.
- NCIT_C189826 referenceCount "1" @default.
- NCIT_C189826 hasExactSynonym "MB-1707" @default.
- NCIT_C189826 hasExactSynonym "MB1707" @default.
- NCIT_C189826 hasExactSynonym "PDC MB1707" @default.
- NCIT_C189826 hasExactSynonym "Paclitaxel-conjugated CXC Chemokine Receptor 4 Antagonist MB1707" @default.
- NCIT_C189826 hasExactSynonym "Paclitaxel-conjugated CXCR4 Peptide Antagonist MB1707" @default.
- NCIT_C189826 hasExactSynonym "Peptide-drug Conjugate MB1707" @default.
- NCIT_C189826 inSubset NCIT_C128784 @default.
- NCIT_C189826 inSubset NCIT_C157711 @default.
- NCIT_C189826 inSubset NCIT_C157712 @default.
- NCIT_C189826 inSubset NCIT_C176424 @default.
- NCIT_C189826 type Class @default.
- NCIT_C189826 isDefinedBy ncit.owl @default.
- NCIT_C189826 label "Paclitaxel-conjugated CXCR4 Peptide Antagonist MB1707" @default.
- NCIT_C189826 subClassOf NCIT_C1490 @default.
- NCIT_C189826 subClassOf NCIT_C186664 @default.
- NCIT_C189826 subClassOf NCIT_C189826 @default.
- NCIT_C189826 subClassOf NCIT_C1908 @default.
- NCIT_C189826 subClassOf NCIT_C1909 @default.
- NCIT_C189826 subClassOf NCIT_C1913 @default.
- NCIT_C189826 subClassOf NCIT_C25974 @default.
- NCIT_C189826 subClassOf NCIT_C273 @default.
- NCIT_C189826 subClassOf NCIT_C274 @default.
- NCIT_C189826 subClassOf NCIT_C552 @default.
- NCIT_C189826 subClassOf NCIT_C616 @default.
- NCIT_C189826 subClassOf NCIT_C67437 @default.
- NCIT_C189826 subClassOf NCIT_C718 @default.
- NCIT_C189826 subClassOf NCIT_C860 @default.