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- NCIT_C189974 IAO_0000115 "A fixed two-agent combination of the sodium salt form of dolutegravir, a human immunodeficiency virus type 1 (HIV-1) integrase strand-transfer inhibitor (INSTI and the hydrochloride salt form of rilpivirine, a non-nucleoside reverse transcriptase (RT) inhibitor (NNRTI), that may be used to treat HIV infection. Upon oral administration of dolutegravir sodium/rilpivirine hydrochloride, dolutegravir binds to the active site of integrase, an HIV enzyme that catalyzes the transfer of viral genetic material into human chromosomes. This prevents integrase from binding to retroviral deoxyribonucleic acid (DNA), and blocks the strand transfer step, which is essential for the HIV replication cycle. Rilpivirine binds to HIV RT, thereby blocking RNA and DNA-dependent DNA polymerase activities including viral replication, thereby further preventing HIV-1 replication." @default.
- NCIT_C189974 NCIT_NHC0 "C189974" @default.
- NCIT_C189974 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189974 NCIT_P108 "Dolutegravir Sodium/Rilpivirine Hydrochloride" @default.
- NCIT_C189974 NCIT_P208 "CL1798503" @default.
- NCIT_C189974 normalizedInformationContent "100" @default.
- NCIT_C189974 referenceCount "1" @default.
- NCIT_C189974 hasExactSynonym "Dolutegravir Sodium/Rilpivirine Hydrochloride" @default.
- NCIT_C189974 hasExactSynonym "Dolutegravir/Rilpivirine" @default.
- NCIT_C189974 hasExactSynonym "Juluca" @default.
- NCIT_C189974 hasExactSynonym "Rilpivirine/Dolutegravir" @default.
- NCIT_C189974 type Class @default.
- NCIT_C189974 isDefinedBy ncit.owl @default.
- NCIT_C189974 label "Dolutegravir Sodium/Rilpivirine Hydrochloride" @default.
- NCIT_C189974 subClassOf NCIT_C157401 @default.
- NCIT_C189974 subClassOf NCIT_C1589 @default.
- NCIT_C189974 subClassOf NCIT_C1660 @default.
- NCIT_C189974 subClassOf NCIT_C189974 @default.
- NCIT_C189974 subClassOf NCIT_C1908 @default.
- NCIT_C189974 subClassOf NCIT_C1909 @default.
- NCIT_C189974 subClassOf NCIT_C254 @default.
- NCIT_C189974 subClassOf NCIT_C281 @default.
- NCIT_C189974 subClassOf NCIT_C471 @default.