Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C189975> ?p ?o ?g. }
Showing items 1 to 25 of
25
with 100 items per page.
- NCIT_C189975 IAO_0000115 "The succinate form of siremadlin, an orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity. Siremadlin inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of both p53 signaling and p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival." @default.
- NCIT_C189975 NCIT_A7 NCIT_C17515 @default.
- NCIT_C189975 NCIT_NHC0 "C189975" @default.
- NCIT_C189975 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189975 NCIT_P108 "Siremadlin Succinate" @default.
- NCIT_C189975 NCIT_P208 "CL1798506" @default.
- NCIT_C189975 NCIT_P210 "1638193-48-2" @default.
- NCIT_C189975 NCIT_P319 "0XPX99P4ZT" @default.
- NCIT_C189975 NCIT_P322 "FDA" @default.
- NCIT_C189975 normalizedInformationContent "100" @default.
- NCIT_C189975 referenceCount "1" @default.
- NCIT_C189975 hasExactSynonym "HDM201 Succinate" @default.
- NCIT_C189975 hasExactSynonym "NVP-HDM201-BBA" @default.
- NCIT_C189975 hasExactSynonym "SIREMADLIN SUCCINATE" @default.
- NCIT_C189975 hasExactSynonym "Siremadlin Succinate" @default.
- NCIT_C189975 inSubset NCIT_C63923 @default.
- NCIT_C189975 type Class @default.
- NCIT_C189975 isDefinedBy ncit.owl @default.
- NCIT_C189975 label "Siremadlin Succinate" @default.
- NCIT_C189975 subClassOf NCIT_C129839 @default.
- NCIT_C189975 subClassOf NCIT_C162996 @default.
- NCIT_C189975 subClassOf NCIT_C189975 @default.
- NCIT_C189975 subClassOf NCIT_C1908 @default.
- NCIT_C189975 subClassOf NCIT_C1909 @default.
- NCIT_C189975 subClassOf NCIT_C274 @default.