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- NCIT_C189976 IAO_0000115 "A fixed two-agent injectable combination of the trihydrate form of meropenem, a broad-spectrum synthetic beta-lactam carbapenem antibiotic, and vaborbactam, a cyclic boronic acid beta-lactamase inhibitor, with antibacterial activity against susceptible bacteria. Upon administration of meropenem trihydrate/vaborbactam, meropenem binds to and inactivates penicillin-binding proteins (PBPs) on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linkage of peptidoglycan chains critical for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Vaborbactam binds to and inhibits beta-lactamase, thereby inhibiting the breakdown of meropenem, and increases the activity and therapeutic effect of meropenem." @default.
- NCIT_C189976 NCIT_NHC0 "C189976" @default.
- NCIT_C189976 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189976 NCIT_P108 "Meropenem Trihydrate/Vaborbactam" @default.
- NCIT_C189976 NCIT_P208 "CL1798505" @default.
- NCIT_C189976 normalizedInformationContent "100" @default.
- NCIT_C189976 referenceCount "1" @default.
- NCIT_C189976 hasExactSynonym "Meropenem Trihydrate/Vaborbactam" @default.
- NCIT_C189976 hasExactSynonym "Meropenem-Vaborbactam" @default.
- NCIT_C189976 hasExactSynonym "Meropenem/Vaborbactam" @default.
- NCIT_C189976 hasExactSynonym "Vabomere" @default.
- NCIT_C189976 hasExactSynonym "Vaborbactam/Meropenem" @default.
- NCIT_C189976 hasExactSynonym "Vaborem" @default.
- NCIT_C189976 type Class @default.
- NCIT_C189976 isDefinedBy ncit.owl @default.
- NCIT_C189976 label "Meropenem Trihydrate/Vaborbactam" @default.
- NCIT_C189976 subClassOf NCIT_C183118 @default.
- NCIT_C189976 subClassOf NCIT_C189976 @default.
- NCIT_C189976 subClassOf NCIT_C1908 @default.
- NCIT_C189976 subClassOf NCIT_C1909 @default.
- NCIT_C189976 subClassOf NCIT_C2140 @default.
- NCIT_C189976 subClassOf NCIT_C254 @default.
- NCIT_C189976 subClassOf NCIT_C258 @default.
- NCIT_C189976 subClassOf NCIT_C260 @default.