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- NCIT_C190037 IAO_0000115 "A preparation of antigen presenting cells (APCs) specific for human papillomavirus (HPV) type 16 E6 and E7 proteins, and engineered to express the costimulatory molecule CD86 and the membrane-bound cytokines interleukin-2 (mbIL-2) and interleukin-12 (mbIL-12), with potential immunomodulating and antineoplastic activities. Autologous peripheral blood mononuclear cells (PBMCs) are ex vivo engineered with five mRNA encoding for HPV 16 E6/E7 antigens, CD86, mbIL-2 and mbIL-12; the resulting APCs present the antigens in a major histocompatibility type I (MHC-I) manner. Upon administration of the APCs-expressing HPV16 E6/E7/CD86/mbIL-2/mbIL-12 SQZ-eAPC-HPV, these cells activate the immune system to mount a cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing HPV16 E6 and E7. The costimulatory molecule CD86 and the cytokines mbIL-2 and mbIL-12 further activate the immune system by promoting the secretion of interferon-gamma (IFNg), activating natural killer cells (NKs), and inducing CTL responses, further killing tumor cells. HPV16 E6 and E7 play an important role in the development of certain types of cancer." @default.
- NCIT_C190037 NCIT_A7 NCIT_C1179 @default.
- NCIT_C190037 NCIT_A7 NCIT_C1397 @default.
- NCIT_C190037 NCIT_NHC0 "C190037" @default.
- NCIT_C190037 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190037 NCIT_P107 "Antigen-presenting Cells-expressing HPV16 E6/E7/CD86/mbIL-2/mbIL-12 SQZ-eAPC-HPV" @default.
- NCIT_C190037 NCIT_P108 "Antigen-presenting Cells-expressing HPV16 E6/E7/CD86/mbIL-2/mbIL-12 SQZ-eAPC-HPV" @default.
- NCIT_C190037 NCIT_P208 "CL1798867" @default.
- NCIT_C190037 NCIT_P322 "CTRP" @default.
- NCIT_C190037 NCIT_P322 "GDC" @default.
- NCIT_C190037 NCIT_P399 "813246" @default.
- NCIT_C190037 normalizedInformationContent "100" @default.
- NCIT_C190037 referenceCount "1" @default.
- NCIT_C190037 hasExactSynonym "APCs-expressing HPV16 E6/E7/CD86/mbIL-2/mbIL-12 SQZ-eAPC-HPV" @default.
- NCIT_C190037 hasExactSynonym "Antigen-presenting Cells-expressing HPV16 E6/E7/CD86/mbIL-2/mbIL-12 SQZ-eAPC-HPV" @default.
- NCIT_C190037 hasExactSynonym "SQZ-eAPC-HPV" @default.
- NCIT_C190037 inSubset NCIT_C116977 @default.
- NCIT_C190037 inSubset NCIT_C116978 @default.
- NCIT_C190037 inSubset NCIT_C128784 @default.
- NCIT_C190037 inSubset NCIT_C157711 @default.
- NCIT_C190037 inSubset NCIT_C157712 @default.
- NCIT_C190037 inSubset NCIT_C176424 @default.
- NCIT_C190037 type Class @default.
- NCIT_C190037 isDefinedBy ncit.owl @default.
- NCIT_C190037 label "Antigen-presenting Cells-expressing HPV16 E6/E7/CD86/mbIL-2/mbIL-12 SQZ-eAPC-HPV" @default.
- NCIT_C190037 subClassOf NCIT_C129820 @default.
- NCIT_C190037 subClassOf NCIT_C1663 @default.
- NCIT_C190037 subClassOf NCIT_C190037 @default.
- NCIT_C190037 subClassOf NCIT_C1908 @default.
- NCIT_C190037 subClassOf NCIT_C1909 @default.
- NCIT_C190037 subClassOf NCIT_C274 @default.
- NCIT_C190037 subClassOf NCIT_C307 @default.
- NCIT_C190037 subClassOf NCIT_C308 @default.
- NCIT_C190037 subClassOf NCIT_C923 @default.