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- NCIT_C190120 IAO_0000115 "An orally bioavailable small molecule inhibitor of the serine/threonine protein kinase Aurora A, with potential antimitotic and antineoplastic activities. Upon oral administration, Aurora A kinase inhibitor JAB-2485 binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, inhibition of cell division and the induction of apoptosis in cells overexpressing Aurora A kinase. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis; it plays an essential role in the regulation of spindle assembly. Aurora kinase A is overexpressed in a wide variety of cancers." @default.
- NCIT_C190120 NCIT_A7 NCIT_C30006 @default.
- NCIT_C190120 NCIT_NHC0 "C190120" @default.
- NCIT_C190120 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190120 NCIT_P107 "Aurora A Kinase Inhibitor JAB-2485" @default.
- NCIT_C190120 NCIT_P108 "Aurora A Kinase Inhibitor JAB-2485" @default.
- NCIT_C190120 NCIT_P208 "CL1798784" @default.
- NCIT_C190120 NCIT_P322 "CTRP" @default.
- NCIT_C190120 NCIT_P322 "GDC" @default.
- NCIT_C190120 NCIT_P399 "810541" @default.
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- NCIT_C190120 NCIT_R146 NCIT_C17018 @default.
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- NCIT_C190120 NCIT_R146 NCIT_C17210 @default.
- NCIT_C190120 NCIT_R146 NCIT_C17325 @default.
- NCIT_C190120 NCIT_R146 NCIT_C20027 @default.
- NCIT_C190120 NCIT_R146 NCIT_C26548 @default.
- NCIT_C190120 NCIT_R146 NCIT_C30006 @default.
- NCIT_C190120 normalizedInformationContent "100" @default.
- NCIT_C190120 referenceCount "1" @default.
- NCIT_C190120 hasExactSynonym "Aurora A Inhibitor JAB-2485" @default.
- NCIT_C190120 hasExactSynonym "Aurora A Kinase Inhibitor JAB-2485" @default.
- NCIT_C190120 hasExactSynonym "JAB 2485" @default.
- NCIT_C190120 hasExactSynonym "JAB-2485" @default.
- NCIT_C190120 hasExactSynonym "JAB2485" @default.
- NCIT_C190120 inSubset NCIT_C116977 @default.
- NCIT_C190120 inSubset NCIT_C116978 @default.
- NCIT_C190120 inSubset NCIT_C128784 @default.
- NCIT_C190120 inSubset NCIT_C157711 @default.
- NCIT_C190120 inSubset NCIT_C157712 @default.
- NCIT_C190120 inSubset NCIT_C176424 @default.
- NCIT_C190120 type Class @default.
- NCIT_C190120 isDefinedBy ncit.owl @default.
- NCIT_C190120 label "Aurora A Kinase Inhibitor JAB-2485" @default.
- NCIT_C190120 subClassOf NCIT_C1404 @default.
- NCIT_C190120 subClassOf NCIT_C190120 @default.
- NCIT_C190120 subClassOf NCIT_C1908 @default.
- NCIT_C190120 subClassOf NCIT_C1909 @default.
- NCIT_C190120 subClassOf NCIT_C471 @default.
- NCIT_C190120 subClassOf NCIT_C61074 @default.
- NCIT_C190120 subClassOf NCIT_C62556 @default.