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- NCIT_C190151 IAO_0000115 "A topical gel formulation containing the macrolide sirolimus (rapamycin), with potential anti-proliferative and chemopreventive activities. Upon topical administration of sirolimus topical gel PTX-022, sirolimus migrates into the basal keratinocytes and is internalized by the affected cells. In turn, sirolimus binds to the immunophilin FK binding protein-12 (FKBP-12) and forms a sirolimus-FKBP-12 complex. This complex binds to and inhibits the activity of the serine/threonine kinase mammalian target of rapamycin (mTOR) and the mTOR-mediated signaling pathways, which reduces cellular proliferation in mTOR-overexpressing cells. Additionally, by inhibiting mTOR, PTX-022 may inhibit translation of mutant keratin mRNAs and the production of mutant keratins in cells in which mutant keratin genes dysregulate keratinocyte proliferation." @default.
- NCIT_C190151 NCIT_A7 NCIT_C102485 @default.
- NCIT_C190151 NCIT_NHC0 "C190151" @default.
- NCIT_C190151 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190151 NCIT_P108 "Sirolimus Topical Gel NPC-12Y" @default.
- NCIT_C190151 NCIT_P208 "CL1798751" @default.
- NCIT_C190151 NCIT_P322 "GDC" @default.
- NCIT_C190151 NCIT_P399 "810554" @default.
- NCIT_C190151 normalizedInformationContent "100" @default.
- NCIT_C190151 referenceCount "1" @default.
- NCIT_C190151 hasExactSynonym "NPC 12Y" @default.
- NCIT_C190151 hasExactSynonym "NPC-12Y" @default.
- NCIT_C190151 hasExactSynonym "NPC12Y" @default.
- NCIT_C190151 hasExactSynonym "Sirolimus Topical Gel NPC-12Y" @default.
- NCIT_C190151 hasExactSynonym "Topical Sirolimus Gel NPC-12Y" @default.
- NCIT_C190151 inSubset NCIT_C128784 @default.
- NCIT_C190151 inSubset NCIT_C157711 @default.
- NCIT_C190151 inSubset NCIT_C157712 @default.
- NCIT_C190151 inSubset NCIT_C176424 @default.
- NCIT_C190151 type Class @default.
- NCIT_C190151 isDefinedBy ncit.owl @default.
- NCIT_C190151 label "Sirolimus Topical Gel NPC-12Y" @default.
- NCIT_C190151 subClassOf NCIT_C190151 @default.
- NCIT_C190151 subClassOf NCIT_C1908 @default.
- NCIT_C190151 subClassOf NCIT_C1909 @default.
- NCIT_C190151 subClassOf NCIT_C308 @default.
- NCIT_C190151 subClassOf NCIT_C574 @default.