Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C190159> ?p ?o ?g. }
Showing items 1 to 36 of
36
with 100 items per page.
- NCIT_C190159 IAO_0000115 "A monoclonal antibody directed against a specific epitope of the insulin-like growth factor-binding protein 7 (IGFBP7) receptor complement component C1q receptor (C1QR1; CD93), with potential antineoplastic activity. Upon administration, anti-CD93 monoclonal antibody DCBY02 targets and binds to CD93 expressed on tumor-associated endothelial cells. This prevents the interaction of CD93 with its ligand IGFBP7, which improves tumor vascular function, reduces tumor hypoxia and increases tumor perfusion. This enhances immune cell infiltration into the tumor microenvironment (TME) and inhibits tumor cell proliferation. CD93 blockade and the normalization of tumor vasculature may also improve the delivery of other antineoplastic agents, thereby enhancing their antitumor effect. In addition, by increasing intratumoral effector T-cells in the TME, DCSZ11 may enhance the efficacy of certain immunotherapeutic agents. CD93, a C-type lectin transmembrane protein, is upregulated in tumor-associated endothelial cells. Its expression is correlated with tumor vascular dysfunction and decreased immune cell infiltration." @default.
- NCIT_C190159 NCIT_A7 NCIT_C73534 @default.
- NCIT_C190159 NCIT_NHC0 "C190159" @default.
- NCIT_C190159 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190159 NCIT_P107 "Anti-CD93 Monoclonal Antibody DCBY02" @default.
- NCIT_C190159 NCIT_P108 "Anti-CD93 Monoclonal Antibody DCBY02" @default.
- NCIT_C190159 NCIT_P208 "CL1798759" @default.
- NCIT_C190159 NCIT_P322 "CTRP" @default.
- NCIT_C190159 NCIT_P322 "GDC" @default.
- NCIT_C190159 NCIT_P399 "810560" @default.
- NCIT_C190159 NCIT_R124 NCIT_C17710 @default.
- NCIT_C190159 NCIT_R124 NCIT_C17828 @default.
- NCIT_C190159 NCIT_R124 NCIT_C18219 @default.
- NCIT_C190159 NCIT_R124 NCIT_C19986 @default.
- NCIT_C190159 NCIT_R124 NCIT_C40474 @default.
- NCIT_C190159 normalizedInformationContent "100" @default.
- NCIT_C190159 referenceCount "1" @default.
- NCIT_C190159 hasExactSynonym "Anti-CD93 Monoclonal Antibody DCBY02" @default.
- NCIT_C190159 hasExactSynonym "DCBY 02" @default.
- NCIT_C190159 hasExactSynonym "DCBY-02" @default.
- NCIT_C190159 hasExactSynonym "DCBY02" @default.
- NCIT_C190159 inSubset NCIT_C116977 @default.
- NCIT_C190159 inSubset NCIT_C116978 @default.
- NCIT_C190159 inSubset NCIT_C128784 @default.
- NCIT_C190159 inSubset NCIT_C157711 @default.
- NCIT_C190159 inSubset NCIT_C157712 @default.
- NCIT_C190159 inSubset NCIT_C176424 @default.
- NCIT_C190159 type Class @default.
- NCIT_C190159 isDefinedBy ncit.owl @default.
- NCIT_C190159 label "Anti-CD93 Monoclonal Antibody DCBY02" @default.
- NCIT_C190159 subClassOf NCIT_C190159 @default.
- NCIT_C190159 subClassOf NCIT_C1908 @default.
- NCIT_C190159 subClassOf NCIT_C1909 @default.
- NCIT_C190159 subClassOf NCIT_C20401 @default.
- NCIT_C190159 subClassOf NCIT_C307 @default.
- NCIT_C190159 subClassOf NCIT_C308 @default.