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- NCIT_C190597 IAO_0000115 "A Toll-like receptor (TLR) agonist antibody conjugate (TRAAC) composed of an unmethylated oligonucleotide-based TLR 9 agonist (T-CpG) conjugated to an antibody that is directed against the B-cell restricted antigen CD22, with potential immunostimulating and antineoplastic activities. Upon intravenous administration of TRAAC TAC-001, the anti-CD22 antibody moiety targets and binds to CD22 on B-cells, including tumor-infiltrating B-cells, thereby systemically delivering T-CpG to B-cells. In turn, the TLR9 agonist binds to the TLR9 receptor expressed on tumor-infiltrating B-cells in the tumor microenvironment (TME), which activates B-cells and induces TLR-mediated signaling. This activates innate and adaptive immune responses and leads to a cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response. TLR9, a member of the TLR family, plays a fundamental role in pathogen recognition and activation of the innate immune system. CD22, a cell surface glycoprotein, is expressed on mature B-cells and on most malignant B-cells." @default.
- NCIT_C190597 NCIT_A7 NCIT_C96048 @default.
- NCIT_C190597 NCIT_NHC0 "C190597" @default.
- NCIT_C190597 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190597 NCIT_P107 "Toll-like Receptor Agonist Antibody Conjugate TAC-001" @default.
- NCIT_C190597 NCIT_P108 "Toll-like Receptor Agonist Antibody Conjugate TAC-001" @default.
- NCIT_C190597 NCIT_P208 "CL1799129" @default.
- NCIT_C190597 NCIT_P322 "CTRP" @default.
- NCIT_C190597 normalizedInformationContent "100" @default.
- NCIT_C190597 referenceCount "1" @default.
- NCIT_C190597 hasExactSynonym "Anti-CD22-T-CpG Conjugate TAC-001" @default.
- NCIT_C190597 hasExactSynonym "TAC 001" @default.
- NCIT_C190597 hasExactSynonym "TAC-001" @default.
- NCIT_C190597 hasExactSynonym "TAC001" @default.
- NCIT_C190597 hasExactSynonym "TLR9 Agonist/Anti-CD22 Antibody Conjugate TAC-001" @default.
- NCIT_C190597 hasExactSynonym "TRAAC TAC-001" @default.
- NCIT_C190597 hasExactSynonym "Toll-like Receptor Agonist Antibody Conjugate TAC-001" @default.
- NCIT_C190597 inSubset NCIT_C116977 @default.
- NCIT_C190597 inSubset NCIT_C116978 @default.
- NCIT_C190597 inSubset NCIT_C176424 @default.
- NCIT_C190597 type Class @default.
- NCIT_C190597 isDefinedBy ncit.owl @default.
- NCIT_C190597 label "Toll-like Receptor Agonist Antibody Conjugate TAC-001" @default.
- NCIT_C190597 subClassOf NCIT_C177174 @default.
- NCIT_C190597 subClassOf NCIT_C177175 @default.
- NCIT_C190597 subClassOf NCIT_C190597 @default.
- NCIT_C190597 subClassOf NCIT_C1908 @default.
- NCIT_C190597 subClassOf NCIT_C1909 @default.
- NCIT_C190597 subClassOf NCIT_C2139 @default.
- NCIT_C190597 subClassOf NCIT_C308 @default.