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- NCIT_C19064 IAO_0000115 "Bone marrow-derived stem cells in the thymus become educated to recognize complexes of self-major histocompatibility complex (MHC) molecules plus self-peptides in a process called positive selection under the influence of epithelial cells in the thymic cortex. Positively-selected thymic T cell precursors (thymocytes) then progress through a process called negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction where self-reactive, and potentially autoimmunity-inducing, thymocytes are deleted. Thymocytes simultaneously progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor. They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells." @default.
- NCIT_C19064 NCIT_NHC0 "C19064" @default.
- NCIT_C19064 NCIT_P106 "Cell Function" @default.
- NCIT_C19064 NCIT_P108 "Thymic T-Cell Selection" @default.
- NCIT_C19064 NCIT_P207 "C1515433" @default.
- NCIT_C19064 NCIT_P366 "Thymocyte_Selection" @default.
- NCIT_C19064 NCIT_R28 NCIT_C16395 @default.
- NCIT_C19064 NCIT_R28 NCIT_C17828 @default.
- NCIT_C19064 NCIT_R28 NCIT_C21124 @default.
- NCIT_C19064 NCIT_R30 NCIT_C12219 @default.
- NCIT_C19064 NCIT_R30 NCIT_C12508 @default.
- NCIT_C19064 NCIT_R30 NCIT_C21599 @default.
- NCIT_C19064 NCIT_R31 NCIT_C12219 @default.
- NCIT_C19064 NCIT_R31 NCIT_C12476 @default.
- NCIT_C19064 NCIT_R31 NCIT_C12508 @default.
- NCIT_C19064 NCIT_R31 NCIT_C12535 @default.
- NCIT_C19064 NCIT_R31 NCIT_C21599 @default.
- NCIT_C19064 NCIT_R31 NCIT_C32725 @default.
- NCIT_C19064 NCIT_R31 NCIT_C39567 @default.
- NCIT_C19064 NCIT_R35 NCIT_C17828 @default.
- NCIT_C19064 NCIT_R35 NCIT_C17937 @default.
- NCIT_C19064 NCIT_R35 NCIT_C18839 @default.
- NCIT_C19064 NCIT_R35 NCIT_C21124 @default.
- NCIT_C19064 NCIT_R35 NCIT_C21128 @default.
- NCIT_C19064 NCIT_R35 NCIT_C21147 @default.
- NCIT_C19064 normalizedInformationContent "83.027314241919257" @default.
- NCIT_C19064 referenceCount "13" @default.
- NCIT_C19064 hasExactSynonym "Thymic T-Cell Selection" @default.
- NCIT_C19064 hasExactSynonym "Thymocyte Selection" @default.
- NCIT_C19064 type Class @default.
- NCIT_C19064 isDefinedBy ncit.owl @default.
- NCIT_C19064 label "Thymic T-Cell Selection" @default.
- NCIT_C19064 subClassOf NCIT_C16399 @default.
- NCIT_C19064 subClassOf NCIT_C17828 @default.
- NCIT_C19064 subClassOf NCIT_C19055 @default.
- NCIT_C19064 subClassOf NCIT_C19064 @default.
- NCIT_C19064 subClassOf NCIT_C19317 @default.
- NCIT_C19064 subClassOf NCIT_C20480 @default.