Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C190683> ?p ?o ?g. }
Showing items 1 to 29 of
29
with 100 items per page.
- NCIT_C190683 IAO_0000115 "A fixed combination of darunavir, a human immunodeficiency virus type 1 (HIV-1) protease nonpeptidic inhibitor, and ritonavir, a cytochrome P450 3A4 (CYP3A4) inhibitor, that may be used to treat HIV-1 infection. Upon oral administration of darunavir/ritonavir, darunavir selectively targets and binds to the active site of HIV-1 protease, and inhibits the dimerization and catalytic activity of HIV-1 protease. This inhibits the proteolytic cleavage of viral Gag and Gag-Pol polyproteins in HIV-infected cells. This inhibition leads to the production of immature, non-infectious viral proteins that are unable to form mature virions, and prevents HIV replication. Ritonavir inhibits CYP3A4, thereby limiting the metabolism of darunavir, which is a CYP3A4 substrate. This leads to an increased concentration and half-life of darunavir as compared to the administration of darunavir without ritonavir." @default.
- NCIT_C190683 NCIT_NHC0 "C190683" @default.
- NCIT_C190683 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190683 NCIT_P107 "Darunavir/Ritonavir" @default.
- NCIT_C190683 NCIT_P108 "Darunavir/Ritonavir" @default.
- NCIT_C190683 NCIT_P208 "CL1799098" @default.
- NCIT_C190683 NCIT_P322 "CTRP" @default.
- NCIT_C190683 NCIT_P399 "813355" @default.
- NCIT_C190683 normalizedInformationContent "100" @default.
- NCIT_C190683 referenceCount "1" @default.
- NCIT_C190683 hasExactSynonym "DRV/r" @default.
- NCIT_C190683 hasExactSynonym "Darunavir-Ritonavir" @default.
- NCIT_C190683 hasExactSynonym "Darunavir/Ritonavir" @default.
- NCIT_C190683 hasExactSynonym "Ritonavir/Darunavir" @default.
- NCIT_C190683 inSubset NCIT_C116977 @default.
- NCIT_C190683 inSubset NCIT_C116978 @default.
- NCIT_C190683 inSubset NCIT_C176424 @default.
- NCIT_C190683 type Class @default.
- NCIT_C190683 isDefinedBy ncit.owl @default.
- NCIT_C190683 label "Darunavir/Ritonavir" @default.
- NCIT_C190683 subClassOf NCIT_C1660 @default.
- NCIT_C190683 subClassOf NCIT_C190683 @default.
- NCIT_C190683 subClassOf NCIT_C1908 @default.
- NCIT_C190683 subClassOf NCIT_C1909 @default.
- NCIT_C190683 subClassOf NCIT_C254 @default.
- NCIT_C190683 subClassOf NCIT_C281 @default.
- NCIT_C190683 subClassOf NCIT_C471 @default.
- NCIT_C190683 subClassOf NCIT_C783 @default.
- NCIT_C190683 subClassOf NCIT_C97366 @default.