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- NCIT_C190686 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting folate receptor alpha (FRa; FolRa; FOLR1) conjugated to an as of yet undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration of anti-FRa ADC AMT-151, the antibody moiety targets and binds to FRa expressed on tumor cells. Upon cellular uptake and internalization, the cytotoxic agent inhibits tumor cell proliferation through an as of yet undisclosed mechanism of action (MoA). FRa is a glycosylphosphatidylinositol linked cell-surface glycoprotein that is widely expressed in certain cancers while its expression is limited in normal tissues." @default.
- NCIT_C190686 NCIT_A7 NCIT_C39284 @default.
- NCIT_C190686 NCIT_NHC0 "C190686" @default.
- NCIT_C190686 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190686 NCIT_P108 "Anti-folate Receptor Alpha Antibody-drug Conjugate AMT-151" @default.
- NCIT_C190686 NCIT_P208 "CL1799101" @default.
- NCIT_C190686 NCIT_P322 "GDC" @default.
- NCIT_C190686 NCIT_P399 "810721" @default.
- NCIT_C190686 normalizedInformationContent "100" @default.
- NCIT_C190686 referenceCount "1" @default.
- NCIT_C190686 hasExactSynonym "AMT 151" @default.
- NCIT_C190686 hasExactSynonym "AMT-151" @default.
- NCIT_C190686 hasExactSynonym "AMT151" @default.
- NCIT_C190686 hasExactSynonym "Anti-FOLR1 ADC AMT-151" @default.
- NCIT_C190686 hasExactSynonym "Anti-FRa ADC AMT-151" @default.
- NCIT_C190686 hasExactSynonym "Anti-FolRa ADC AMT-151" @default.
- NCIT_C190686 hasExactSynonym "Anti-folate Receptor Alpha ADC AMT-151" @default.
- NCIT_C190686 hasExactSynonym "Anti-folate Receptor Alpha Antibody-drug Conjugate AMT-151" @default.
- NCIT_C190686 inSubset NCIT_C128784 @default.
- NCIT_C190686 inSubset NCIT_C157711 @default.
- NCIT_C190686 inSubset NCIT_C157712 @default.
- NCIT_C190686 inSubset NCIT_C176424 @default.
- NCIT_C190686 type Class @default.
- NCIT_C190686 isDefinedBy ncit.owl @default.
- NCIT_C190686 label "Anti-folate Receptor Alpha Antibody-drug Conjugate AMT-151" @default.
- NCIT_C190686 subClassOf NCIT_C129821 @default.
- NCIT_C190686 subClassOf NCIT_C129823 @default.
- NCIT_C190686 subClassOf NCIT_C1512 @default.
- NCIT_C190686 subClassOf NCIT_C163758 @default.
- NCIT_C190686 subClassOf NCIT_C190686 @default.
- NCIT_C190686 subClassOf NCIT_C1908 @default.
- NCIT_C190686 subClassOf NCIT_C1909 @default.
- NCIT_C190686 subClassOf NCIT_C200086 @default.
- NCIT_C190686 subClassOf NCIT_C200114 @default.
- NCIT_C190686 subClassOf NCIT_C274 @default.
- NCIT_C190686 subClassOf NCIT_C307 @default.
- NCIT_C190686 subClassOf NCIT_C308 @default.