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- NCIT_C190687 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin 18.2 (CLDN18.2; A2 isoform of claudin-18) conjugated to the microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration, anti-CLDN18.2 ADC JS107 specifically targets and binds to CLDN18.2 expressed on tumor cells. Upon internalization and the release of MMAE, MMAE targets and binds to tubulin, and inhibits microtubule polymerization. This results in G2/M phase cell cycle arrest and apoptosis in CLDN18.2-expressing tumor cells. In addition, JS107 kills tumor cells via antibody-dependent cellular cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC). CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C190687 NCIT_A7 NCIT_C150412 @default.
- NCIT_C190687 NCIT_NHC0 "C190687" @default.
- NCIT_C190687 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190687 NCIT_P108 "Anti-Claudin 18.2 Antibody-drug Conjugate JS107" @default.
- NCIT_C190687 NCIT_P208 "CL1799102" @default.
- NCIT_C190687 NCIT_P322 "GDC" @default.
- NCIT_C190687 NCIT_P399 "810723" @default.
- NCIT_C190687 normalizedInformationContent "100" @default.
- NCIT_C190687 referenceCount "1" @default.
- NCIT_C190687 hasExactSynonym "ADC JS107" @default.
- NCIT_C190687 hasExactSynonym "Anti-CLDN18.2 ADC JS107" @default.
- NCIT_C190687 hasExactSynonym "Anti-Claudin 18.2 ADC JS107" @default.
- NCIT_C190687 hasExactSynonym "Anti-Claudin 18.2 Antibody-drug Conjugate JS107" @default.
- NCIT_C190687 hasExactSynonym "Anti-Claudin 18.2/MMAE Antibody-drug Conjugate JS107" @default.
- NCIT_C190687 hasExactSynonym "JS 107" @default.
- NCIT_C190687 hasExactSynonym "JS-107" @default.
- NCIT_C190687 hasExactSynonym "JS107" @default.
- NCIT_C190687 inSubset NCIT_C128784 @default.
- NCIT_C190687 inSubset NCIT_C157711 @default.
- NCIT_C190687 inSubset NCIT_C157712 @default.
- NCIT_C190687 inSubset NCIT_C176424 @default.
- NCIT_C190687 type Class @default.
- NCIT_C190687 isDefinedBy ncit.owl @default.
- NCIT_C190687 label "Anti-Claudin 18.2 Antibody-drug Conjugate JS107" @default.
- NCIT_C190687 subClassOf NCIT_C129821 @default.
- NCIT_C190687 subClassOf NCIT_C129823 @default.
- NCIT_C190687 subClassOf NCIT_C1512 @default.
- NCIT_C190687 subClassOf NCIT_C163758 @default.
- NCIT_C190687 subClassOf NCIT_C190687 @default.
- NCIT_C190687 subClassOf NCIT_C1908 @default.
- NCIT_C190687 subClassOf NCIT_C1909 @default.
- NCIT_C190687 subClassOf NCIT_C200250 @default.
- NCIT_C190687 subClassOf NCIT_C200251 @default.
- NCIT_C190687 subClassOf NCIT_C274 @default.
- NCIT_C190687 subClassOf NCIT_C307 @default.
- NCIT_C190687 subClassOf NCIT_C308 @default.