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- NCIT_C190707 IAO_0000115 "A preparation of genetically modified T-cells transduced expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing the CD28 signaling domain fused to CD3 zeta, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing T-lymphocytes are directed to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered T-cells and can promote elimination of those cells upon a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response. The costimulatory signaling domain enhances proliferation of T-cells and antitumor activity. CD19R(EQ) contains two-point mutations in the immunoglobulin (Ig) G4 Fc spacer region, thereby preventing recognition of the CAR by Fc gamma receptors (FcgammaRs)." @default.
- NCIT_C190707 NCIT_A7 NCIT_C38894 @default.
- NCIT_C190707 NCIT_NHC0 "C190707" @default.
- NCIT_C190707 NCIT_P106 "Cell" @default.
- NCIT_C190707 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190707 NCIT_P107 "CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing T-lymphocytes" @default.
- NCIT_C190707 NCIT_P108 "CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing T-lymphocytes" @default.
- NCIT_C190707 NCIT_P208 "CL1799391" @default.
- NCIT_C190707 NCIT_P322 "CTRP" @default.
- NCIT_C190707 NCIT_P322 "GDC" @default.
- NCIT_C190707 NCIT_P399 "811235" @default.
- NCIT_C190707 normalizedInformationContent "100" @default.
- NCIT_C190707 referenceCount "1" @default.
- NCIT_C190707 hasExactSynonym "CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing T-lymphocytes" @default.
- NCIT_C190707 hasExactSynonym "CD19R(EQ)28zeta/EGFRt+ T Cells" @default.
- NCIT_C190707 hasExactSynonym "CD19R(EQ)28zeta/EGFRt+ T-cells" @default.
- NCIT_C190707 hasExactSynonym "CD19R(EQ)28zeta/truncated Human EGFR+ T-cells" @default.
- NCIT_C190707 inSubset NCIT_C116977 @default.
- NCIT_C190707 inSubset NCIT_C116978 @default.
- NCIT_C190707 inSubset NCIT_C128784 @default.
- NCIT_C190707 inSubset NCIT_C157711 @default.
- NCIT_C190707 inSubset NCIT_C157712 @default.
- NCIT_C190707 inSubset NCIT_C176424 @default.
- NCIT_C190707 type Class @default.
- NCIT_C190707 isDefinedBy ncit.owl @default.
- NCIT_C190707 label "CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing T-lymphocytes" @default.
- NCIT_C190707 subClassOf NCIT_C129820 @default.
- NCIT_C190707 subClassOf NCIT_C129821 @default.
- NCIT_C190707 subClassOf NCIT_C129826 @default.
- NCIT_C190707 subClassOf NCIT_C137999 @default.
- NCIT_C190707 subClassOf NCIT_C142078 @default.
- NCIT_C190707 subClassOf NCIT_C154231 @default.
- NCIT_C190707 subClassOf NCIT_C176018 @default.
- NCIT_C190707 subClassOf NCIT_C190707 @default.
- NCIT_C190707 subClassOf NCIT_C1908 @default.
- NCIT_C190707 subClassOf NCIT_C1909 @default.
- NCIT_C190707 subClassOf NCIT_C1962 @default.
- NCIT_C190707 subClassOf NCIT_C274 @default.
- NCIT_C190707 subClassOf NCIT_C307 @default.
- NCIT_C190707 subClassOf NCIT_C308 @default.