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- NCIT_C190717 IAO_0000115 "A bispecific antibody targeting both CD137 (4-1BB; tumor necrosis factor receptor superfamily member 9; TNFRSF9) and fibroblast activation protein (FAP), with potential immunomodulating and antineoplastic activities. Upon administration, anti-CD137/anti-FAP bispecific antibody BI 765179 targets and binds to both FAP, expressed on cancer-associated fibroblasts (CAFs) in the tumor stroma, and CD137, expressed on the surface of immune cells including activated T-lymphocytes, natural killer (NK) cells and dendritic cells (DCs). The simultaneous binding of FAP and CD137 results in local clustering of FAP-expressing CAFs and CD137-expressing T-cells in the tumor microenvironment (TME), local immune cell activation through the promotion of T-cell activation and cytokine release, and T-cell-mediated anti-tumor immune responses. CD137, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity. FAP, a membrane-bound serine protease overexpressed on CAFs, is minimally expressed on normal, healthy cells." @default.
- NCIT_C190717 NCIT_A7 NCIT_C105113 @default.
- NCIT_C190717 NCIT_A7 NCIT_C17799 @default.
- NCIT_C190717 NCIT_NHC0 "C190717" @default.
- NCIT_C190717 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190717 NCIT_P107 "Anti-CD137/Anti-FAP Bispecific Antibody BI 765179" @default.
- NCIT_C190717 NCIT_P108 "Anti-CD137/Anti-FAP Bispecific Antibody BI 765179" @default.
- NCIT_C190717 NCIT_P208 "CL1799365" @default.
- NCIT_C190717 NCIT_P322 "CTRP" @default.
- NCIT_C190717 NCIT_P322 "GDC" @default.
- NCIT_C190717 NCIT_R124 NCIT_C17710 @default.
- NCIT_C190717 NCIT_R124 NCIT_C17828 @default.
- NCIT_C190717 NCIT_R124 NCIT_C18219 @default.
- NCIT_C190717 NCIT_R124 NCIT_C19986 @default.
- NCIT_C190717 NCIT_R124 NCIT_C40474 @default.
- NCIT_C190717 normalizedInformationContent "100" @default.
- NCIT_C190717 referenceCount "1" @default.
- NCIT_C190717 hasExactSynonym "4-1BB x FAP Bispecific Antibody BI 765179" @default.
- NCIT_C190717 hasExactSynonym "Anti-4-1BB/Anti-FAP Bispecific Antibody BI 765179" @default.
- NCIT_C190717 hasExactSynonym "Anti-4-1BB/FAP Bispecific Antibody BI 765179" @default.
- NCIT_C190717 hasExactSynonym "Anti-CD137/Anti-FAP Bispecific Antibody BI 765179" @default.
- NCIT_C190717 hasExactSynonym "Anti-CD137/FAP Bispecific Antibody BI 765179" @default.
- NCIT_C190717 hasExactSynonym "BI 765179" @default.
- NCIT_C190717 hasExactSynonym "BI-765179" @default.
- NCIT_C190717 hasExactSynonym "BI765179" @default.
- NCIT_C190717 hasExactSynonym "CD137 x FAP Bispecific Antibody BI 765179" @default.
- NCIT_C190717 hasExactSynonym "CD137/FAP Agonist BI 765179" @default.
- NCIT_C190717 inSubset NCIT_C116977 @default.
- NCIT_C190717 inSubset NCIT_C116978 @default.
- NCIT_C190717 inSubset NCIT_C128784 @default.
- NCIT_C190717 inSubset NCIT_C157711 @default.
- NCIT_C190717 inSubset NCIT_C157712 @default.
- NCIT_C190717 inSubset NCIT_C176424 @default.
- NCIT_C190717 type Class @default.
- NCIT_C190717 isDefinedBy ncit.owl @default.
- NCIT_C190717 label "Anti-CD137/Anti-FAP Bispecific Antibody BI 765179" @default.
- NCIT_C190717 subClassOf NCIT_C129820 @default.
- NCIT_C190717 subClassOf NCIT_C129821 @default.
- NCIT_C190717 subClassOf NCIT_C129822 @default.
- NCIT_C190717 subClassOf NCIT_C1454 @default.
- NCIT_C190717 subClassOf NCIT_C155745 @default.
- NCIT_C190717 subClassOf NCIT_C190717 @default.
- NCIT_C190717 subClassOf NCIT_C1908 @default.
- NCIT_C190717 subClassOf NCIT_C1909 @default.
- NCIT_C190717 subClassOf NCIT_C192997 @default.
- NCIT_C190717 subClassOf NCIT_C20401 @default.
- NCIT_C190717 subClassOf NCIT_C274 @default.
- NCIT_C190717 subClassOf NCIT_C28227 @default.
- NCIT_C190717 subClassOf NCIT_C307 @default.
- NCIT_C190717 subClassOf NCIT_C308 @default.