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- NCIT_C190727 IAO_0000115 "The mesylate salt form of leuprolide, a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH), with potential antineoplastic activity. Upon administration, leuprolide binds to and activates the gonadotropin-releasing hormone receptor (GnRHR). The continuous stimulation of GnRHR by leuprolide results in both the desensitization of pituitary GnRHR and the inhibition of pituitary secretion of the gonadotropins follicle stimulating hormone (FSH) and luteinizing hormone (LH). In males, this results in a significant decline in testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression." @default.
- NCIT_C190727 NCIT_A6 NCIT_C62042 @default.
- NCIT_C190727 NCIT_A7 NCIT_C38910 @default.
- NCIT_C190727 NCIT_NHC0 "C190727" @default.
- NCIT_C190727 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190727 NCIT_P108 "Leuprolide Mesylate" @default.
- NCIT_C190727 NCIT_P208 "CL1799374" @default.
- NCIT_C190727 NCIT_P210 "944347-41-5" @default.
- NCIT_C190727 NCIT_P302 "Prostate cancer" @default.
- NCIT_C190727 NCIT_P319 "8E3C3C493W" @default.
- NCIT_C190727 NCIT_P322 "FDA" @default.
- NCIT_C190727 NCIT_P322 "GDC" @default.
- NCIT_C190727 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C190727 referenceCount "2" @default.
- NCIT_C190727 hasExactSynonym "Camcevi" @default.
- NCIT_C190727 hasExactSynonym "LEUPROLIDE MESYLATE" @default.
- NCIT_C190727 hasExactSynonym "Leuprolide Mesylate" @default.
- NCIT_C190727 inSubset NCIT_C128784 @default.
- NCIT_C190727 inSubset NCIT_C157711 @default.
- NCIT_C190727 inSubset NCIT_C157712 @default.
- NCIT_C190727 inSubset NCIT_C63923 @default.
- NCIT_C190727 type Class @default.
- NCIT_C190727 isDefinedBy ncit.owl @default.
- NCIT_C190727 label "Leuprolide Mesylate" @default.
- NCIT_C190727 subClassOf NCIT_C147908 @default.
- NCIT_C190727 subClassOf NCIT_C190727 @default.
- NCIT_C190727 subClassOf NCIT_C1908 @default.
- NCIT_C190727 subClassOf NCIT_C1909 @default.
- NCIT_C190727 subClassOf NCIT_C1910 @default.
- NCIT_C190727 subClassOf NCIT_C548 @default.