Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C190741> ?p ?o ?g. }
Showing items 1 to 29 of
29
with 100 items per page.
- NCIT_C190741 IAO_0000115 "A soluble protein antigen-receptor X-linker (sparX) protein containing a CD123 tumor-associated antigen (TAA) binding-domain and a TAG domain, which contains a fragment of human alpha fetoprotein (AFP), with binding ability to CD123-specific tumor cells and universal CAR-modified T-cells (antigen-receptor complex-T-cells; ARC-T-cells), respectively. Upon administration, the CD123-specific adapter SPRX002 targets and binds, with its anti-CD123 binding domain, to CD123-expressing tumor cells and, with its TAG region, targets and binds to the anti-TAG binding domain on the ARC-T-cells. When ARC-T-cells bind to the TAG domain of SPRX002 and SPRX002 is bound to CD123-expressing cancer cells, the tricomplex formation leads to T-cell activation, expansion and killing of CD123-expressing cancer cells. The combination of SPRX002 with ARC-T-cells is called ACLX002. Since the dose of SPRX002 can be adjusted, it allows for the controllability and adaptability of the ARC-T-cells and reduces its potential toxicity .CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with both increased leukemic cell proliferation and aggressiveness." @default.
- NCIT_C190741 NCIT_A7 NCIT_C39275 @default.
- NCIT_C190741 NCIT_NHC0 "C190741" @default.
- NCIT_C190741 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190741 NCIT_P107 "CD123-Specific Adapter SPRX002" @default.
- NCIT_C190741 NCIT_P108 "CD123-Specific Adapter SPRX002" @default.
- NCIT_C190741 NCIT_P208 "CL1799386" @default.
- NCIT_C190741 NCIT_P322 "CTRP" @default.
- NCIT_C190741 normalizedInformationContent "100" @default.
- NCIT_C190741 referenceCount "1" @default.
- NCIT_C190741 hasExactSynonym "CD123-Specific Adapter SPRX002" @default.
- NCIT_C190741 hasExactSynonym "Monovalent CD123-Specific Adapter SPRX002" @default.
- NCIT_C190741 hasExactSynonym "Monovalent CD123-targeting Protein SPRX002" @default.
- NCIT_C190741 hasExactSynonym "Protein-targeting CD123 SPRX002" @default.
- NCIT_C190741 hasExactSynonym "SPRX 002" @default.
- NCIT_C190741 hasExactSynonym "SPRX-002" @default.
- NCIT_C190741 hasExactSynonym "SPRX002" @default.
- NCIT_C190741 hasExactSynonym "SparX Protein Targeting CD123 SPRX002" @default.
- NCIT_C190741 hasExactSynonym "TAG Protein SPRX002" @default.
- NCIT_C190741 inSubset NCIT_C116977 @default.
- NCIT_C190741 inSubset NCIT_C116978 @default.
- NCIT_C190741 inSubset NCIT_C176424 @default.
- NCIT_C190741 type Class @default.
- NCIT_C190741 isDefinedBy ncit.owl @default.
- NCIT_C190741 label "CD123-Specific Adapter SPRX002" @default.
- NCIT_C190741 subClassOf NCIT_C190741 @default.
- NCIT_C190741 subClassOf NCIT_C1908 @default.
- NCIT_C190741 subClassOf NCIT_C1909 @default.
- NCIT_C190741 subClassOf NCIT_C307 @default.