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- NCIT_C190744 IAO_0000115 "The hydrochloride salt form of lirafugratinib, an orally bioavailable inhibitor of the fibroblast growth factor receptor 2 (FGFR2), with potential antineoplastic activity. Upon oral administration, lirafugratinib binds to and inhibits FGFR2, which results in the inhibition of FGFR2-mediated signal transduction pathways. This inhibits the proliferation of FGFR2-overexpressing tumor cells. FGFR2, a receptor tyrosine kinase upregulated in many tumor cell types, plays a key role in cellular proliferation, migration and survival." @default.
- NCIT_C190744 NCIT_A7 NCIT_C17411 @default.
- NCIT_C190744 NCIT_NHC0 "C190744" @default.
- NCIT_C190744 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190744 NCIT_P108 "Lirafugratinib Hydrochloride" @default.
- NCIT_C190744 NCIT_P208 "CL1799382" @default.
- NCIT_C190744 NCIT_P210 "2688040-45-9" @default.
- NCIT_C190744 NCIT_P319 "4P76F4XM3B" @default.
- NCIT_C190744 NCIT_P322 "FDA" @default.
- NCIT_C190744 normalizedInformationContent "100" @default.
- NCIT_C190744 referenceCount "1" @default.
- NCIT_C190744 hasExactSynonym "LIRAFUGRATINIB HYDROCHLORIDE" @default.
- NCIT_C190744 hasExactSynonym "Lirafugratinib Hydrochloride" @default.
- NCIT_C190744 hasExactSynonym "RLY 4008 Hydrochloride" @default.
- NCIT_C190744 hasExactSynonym "RLY-4008 Hydrochloride" @default.
- NCIT_C190744 hasExactSynonym "RLY4008 Hydrochloride" @default.
- NCIT_C190744 inSubset NCIT_C128784 @default.
- NCIT_C190744 inSubset NCIT_C63923 @default.
- NCIT_C190744 type Class @default.
- NCIT_C190744 isDefinedBy ncit.owl @default.
- NCIT_C190744 label "Lirafugratinib Hydrochloride" @default.
- NCIT_C190744 subClassOf NCIT_C129824 @default.
- NCIT_C190744 subClassOf NCIT_C129825 @default.
- NCIT_C190744 subClassOf NCIT_C1404 @default.
- NCIT_C190744 subClassOf NCIT_C155727 @default.
- NCIT_C190744 subClassOf NCIT_C163758 @default.
- NCIT_C190744 subClassOf NCIT_C164035 @default.
- NCIT_C190744 subClassOf NCIT_C190744 @default.
- NCIT_C190744 subClassOf NCIT_C1908 @default.
- NCIT_C190744 subClassOf NCIT_C1909 @default.
- NCIT_C190744 subClassOf NCIT_C1967 @default.
- NCIT_C190744 subClassOf NCIT_C2189 @default.
- NCIT_C190744 subClassOf NCIT_C274 @default.
- NCIT_C190744 subClassOf NCIT_C471 @default.