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- NCIT_C190745 IAO_0000115 "An orally bioavailable, selective, active-form inhibitor of tyrosine kinase BCR-ABL fusion oncoprotein, with potential antineoplastic activity. Upon oral administration, BCR-ABL inhibitor ELVN-001 specifically targets and binds to the ATP-binding site in the kinase domain of activated BCR-ABL1, thereby inhibiting the activity of both wild-type BCR-ABL and certain mutation forms, including the T315I mutation. This binding results in the inhibition of BCR-ABL-mediated proliferation and enhanced apoptosis of Philadelphia chromosome-positive (Ph+) hematological malignancies. The BCR-ABL fusion protein tyrosine kinase is an abnormal enzyme produced by leukemia cells that contain the Philadelphia chromosome. The T315I mutation, the most common BCR-ABL mutation, shows resistance to nearly all commonly used tyrosine kinase inhibitors (TKIs)." @default.
- NCIT_C190745 NCIT_A7 NCIT_C16325 @default.
- NCIT_C190745 NCIT_NHC0 "C190745" @default.
- NCIT_C190745 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190745 NCIT_P107 "BCR-ABL Inhibitor ELVN-001" @default.
- NCIT_C190745 NCIT_P108 "BCR-ABL Inhibitor ELVN-001" @default.
- NCIT_C190745 NCIT_P208 "CL1799383" @default.
- NCIT_C190745 NCIT_P322 "CTRP" @default.
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- NCIT_C190745 NCIT_R125 NCIT_C17133 @default.
- NCIT_C190745 NCIT_R125 NCIT_C17828 @default.
- NCIT_C190745 NCIT_R125 NCIT_C18081 @default.
- NCIT_C190745 NCIT_R125 NCIT_C20480 @default.
- NCIT_C190745 NCIT_R125 NCIT_C20751 @default.
- NCIT_C190745 NCIT_R125 NCIT_C40821 @default.
- NCIT_C190745 normalizedInformationContent "100" @default.
- NCIT_C190745 referenceCount "1" @default.
- NCIT_C190745 hasExactSynonym "BCR-ABL Inhibitor ELVN-001" @default.
- NCIT_C190745 hasExactSynonym "BCR-ABL TKI ELVN-001" @default.
- NCIT_C190745 hasExactSynonym "BCR-ABL Tyrosine Kinase Inhibitor ELVN-001" @default.
- NCIT_C190745 hasExactSynonym "ELVN 001" @default.
- NCIT_C190745 hasExactSynonym "ELVN-001" @default.
- NCIT_C190745 hasExactSynonym "ELVN001" @default.
- NCIT_C190745 inSubset NCIT_C116977 @default.
- NCIT_C190745 inSubset NCIT_C116978 @default.
- NCIT_C190745 inSubset NCIT_C128784 @default.
- NCIT_C190745 inSubset NCIT_C176424 @default.
- NCIT_C190745 type Class @default.
- NCIT_C190745 isDefinedBy ncit.owl @default.
- NCIT_C190745 label "BCR-ABL Inhibitor ELVN-001" @default.
- NCIT_C190745 subClassOf NCIT_C129824 @default.
- NCIT_C190745 subClassOf NCIT_C129825 @default.
- NCIT_C190745 subClassOf NCIT_C1404 @default.
- NCIT_C190745 subClassOf NCIT_C155700 @default.
- NCIT_C190745 subClassOf NCIT_C163758 @default.
- NCIT_C190745 subClassOf NCIT_C190745 @default.
- NCIT_C190745 subClassOf NCIT_C1908 @default.
- NCIT_C190745 subClassOf NCIT_C1909 @default.
- NCIT_C190745 subClassOf NCIT_C1967 @default.
- NCIT_C190745 subClassOf NCIT_C2189 @default.
- NCIT_C190745 subClassOf NCIT_C274 @default.
- NCIT_C190745 subClassOf NCIT_C471 @default.