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- NCIT_C190779 IAO_0000115 "An orally bioavailable, selective inhibitor of human fibroblast growth factor receptor 3 (FGFR3), with potential antineoplastic activity. Upon oral administration, FGFR3 inhibitor TYRA-300 specifically targets and binds to certain FGFR3 activating gene alterations, and specifically the gatekeeper mutants V555L/M. This blocks FGFR3-mediated signaling and leads to an inhibition of tumor cell proliferation in FGFR3-overexpressing cells. FGFR3, a receptor tyrosine kinase, is involved in angiogenesis and in the proliferation, differentiation, and survival of tumor cells. FGFR3 expression is associated with poor prognosis. It is overexpressed by certain tumor cell types." @default.
- NCIT_C190779 NCIT_A7 NCIT_C26129 @default.
- NCIT_C190779 NCIT_NHC0 "C190779" @default.
- NCIT_C190779 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190779 NCIT_P107 "FGFR3 Inhibitor TYRA-300" @default.
- NCIT_C190779 NCIT_P108 "FGFR3 Inhibitor TYRA-300" @default.
- NCIT_C190779 NCIT_P208 "CL1799355" @default.
- NCIT_C190779 NCIT_P322 "CTRP" @default.
- NCIT_C190779 NCIT_P322 "GDC" @default.
- NCIT_C190779 NCIT_P399 "811233" @default.
- NCIT_C190779 normalizedInformationContent "100" @default.
- NCIT_C190779 referenceCount "1" @default.
- NCIT_C190779 hasExactSynonym "FGFR3 Inhibitor TYRA-300" @default.
- NCIT_C190779 hasExactSynonym "TYRA 300" @default.
- NCIT_C190779 hasExactSynonym "TYRA-300" @default.
- NCIT_C190779 hasExactSynonym "TYRA300" @default.
- NCIT_C190779 inSubset NCIT_C116977 @default.
- NCIT_C190779 inSubset NCIT_C116978 @default.
- NCIT_C190779 inSubset NCIT_C128784 @default.
- NCIT_C190779 inSubset NCIT_C157711 @default.
- NCIT_C190779 inSubset NCIT_C157712 @default.
- NCIT_C190779 inSubset NCIT_C176424 @default.
- NCIT_C190779 type Class @default.
- NCIT_C190779 isDefinedBy ncit.owl @default.
- NCIT_C190779 label "FGFR3 Inhibitor TYRA-300" @default.
- NCIT_C190779 subClassOf NCIT_C129824 @default.
- NCIT_C190779 subClassOf NCIT_C129825 @default.
- NCIT_C190779 subClassOf NCIT_C1404 @default.
- NCIT_C190779 subClassOf NCIT_C155727 @default.
- NCIT_C190779 subClassOf NCIT_C163758 @default.
- NCIT_C190779 subClassOf NCIT_C164035 @default.
- NCIT_C190779 subClassOf NCIT_C190779 @default.
- NCIT_C190779 subClassOf NCIT_C1908 @default.
- NCIT_C190779 subClassOf NCIT_C1909 @default.
- NCIT_C190779 subClassOf NCIT_C1967 @default.
- NCIT_C190779 subClassOf NCIT_C2189 @default.
- NCIT_C190779 subClassOf NCIT_C274 @default.
- NCIT_C190779 subClassOf NCIT_C471 @default.