Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C190780> ?p ?o ?g. }
Showing items 1 to 50 of
50
with 100 items per page.
- NCIT_C190780 IAO_0000115 "A coformulation containing favezelimab, a humanized, immunoglobulin G4 (IgG4) monoclonal antibody (MAb) directed against the inhibitory receptor lymphocyte activation gene-3 protein (LAG3), and pembrolizumab, a humanized monoclonal IgG4 antibody directed against human cell surface receptor PD-1 (programmed death-1 or programmed cell death-1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration of the favezelimab/pembrolizumab formulation, favezelimab binds to LAG3 expressed on tumor-infiltrating lymphocytes (TILs) and blocks its binding with major histocompatibility complex (MHC) class II molecules expressed on tumor cells. This activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which leads to a reduction in tumor growth. Pembrolizumab binds to PD-1, an inhibitory signaling receptor expressed on the surface of activated T-cells, and blocks the binding to and activation of PD-1 by its ligands, which results in the activation of T-cell-mediated immune responses against tumor cells LAG3, a member of the immunoglobulin superfamily (IgSF) expressed on various immune cells, negatively regulates both proliferation and activation of T-cells. Its expression on TILs is associated with tumor-mediated immune suppression. The ligands for PD-1 include programmed cell death ligand 1 (PD-L1), overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on antigen presenting cells (APCs). Activated PD-1 negatively regulates T-cell activation and plays a key role in in tumor evasion from host immunity." @default.
- NCIT_C190780 NCIT_A7 NCIT_C104623 @default.
- NCIT_C190780 NCIT_A7 NCIT_C94697 @default.
- NCIT_C190780 NCIT_NHC0 "C190780" @default.
- NCIT_C190780 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190780 NCIT_P107 "Favezelimab/Pembrolizumab Formulation" @default.
- NCIT_C190780 NCIT_P108 "Favezelimab/Pembrolizumab Formulation" @default.
- NCIT_C190780 NCIT_P208 "CL1799312" @default.
- NCIT_C190780 NCIT_P322 "CTRP" @default.
- NCIT_C190780 NCIT_P322 "GDC" @default.
- NCIT_C190780 NCIT_R124 NCIT_C17710 @default.
- NCIT_C190780 NCIT_R124 NCIT_C17828 @default.
- NCIT_C190780 NCIT_R124 NCIT_C18219 @default.
- NCIT_C190780 NCIT_R124 NCIT_C19986 @default.
- NCIT_C190780 NCIT_R124 NCIT_C40474 @default.
- NCIT_C190780 normalizedInformationContent "100" @default.
- NCIT_C190780 referenceCount "1" @default.
- NCIT_C190780 hasExactSynonym "Coformulated Favezelimab Plus Pembrolizumab" @default.
- NCIT_C190780 hasExactSynonym "Coformulated Favezelimab/Pembrolizumab" @default.
- NCIT_C190780 hasExactSynonym "Coformulated MK-4280 Plus MK-3475" @default.
- NCIT_C190780 hasExactSynonym "Favezelimab/Pembrolizumab Formulation MK-4280A" @default.
- NCIT_C190780 hasExactSynonym "Favezelimab/Pembrolizumab Formulation" @default.
- NCIT_C190780 hasExactSynonym "MK 4280A" @default.
- NCIT_C190780 hasExactSynonym "MK-4280A" @default.
- NCIT_C190780 hasExactSynonym "MK4280A" @default.
- NCIT_C190780 inSubset NCIT_C116977 @default.
- NCIT_C190780 inSubset NCIT_C116978 @default.
- NCIT_C190780 inSubset NCIT_C128784 @default.
- NCIT_C190780 inSubset NCIT_C157711 @default.
- NCIT_C190780 inSubset NCIT_C157712 @default.
- NCIT_C190780 inSubset NCIT_C176424 @default.
- NCIT_C190780 type Class @default.
- NCIT_C190780 isDefinedBy ncit.owl @default.
- NCIT_C190780 label "Favezelimab/Pembrolizumab Formulation" @default.
- NCIT_C190780 subClassOf NCIT_C124946 @default.
- NCIT_C190780 subClassOf NCIT_C128037 @default.
- NCIT_C190780 subClassOf NCIT_C129821 @default.
- NCIT_C190780 subClassOf NCIT_C129822 @default.
- NCIT_C190780 subClassOf NCIT_C134305 @default.
- NCIT_C190780 subClassOf NCIT_C141144 @default.
- NCIT_C190780 subClassOf NCIT_C143250 @default.
- NCIT_C190780 subClassOf NCIT_C163758 @default.
- NCIT_C190780 subClassOf NCIT_C190780 @default.
- NCIT_C190780 subClassOf NCIT_C1908 @default.
- NCIT_C190780 subClassOf NCIT_C1909 @default.
- NCIT_C190780 subClassOf NCIT_C200483 @default.
- NCIT_C190780 subClassOf NCIT_C20401 @default.
- NCIT_C190780 subClassOf NCIT_C274 @default.
- NCIT_C190780 subClassOf NCIT_C307 @default.
- NCIT_C190780 subClassOf NCIT_C308 @default.