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- NCIT_C190788 IAO_0000115 "An antibody-drug conjugate (ADC) composed of an immunoglobulin G1 (IgG1) monoclonal antibody directed against the tumor-associated antigen (TAA) claudin 18.2 (CLDN18.2; A2 isoform of claudin-18) that is site-specifically conjugated, via a non-cleavable amide/peptide linker, to a derivative of the cytotoxic anthracycline PNU-159682, with potential antineoplastic activity. Upon administration of anti-CLDN18.2 ADC SOT102, the antibody moiety specifically targets and binds to CLDN18.2 expressed on tumor cells. Upon internalization, the anthracycline-based toxin intercalates into DNA and interacts with topoisomerase II. This leads to an inhibition of DNA replication and repair, and prevents RNA and protein synthesis. This kills the CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C190788 NCIT_A7 NCIT_C150412 @default.
- NCIT_C190788 NCIT_NHC0 "C190788" @default.
- NCIT_C190788 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190788 NCIT_P107 "Anti-Claudin 18.2 Antibody-drug Conjugate SOT102" @default.
- NCIT_C190788 NCIT_P108 "Anti-Claudin 18.2 Antibody-drug Conjugate SOT102" @default.
- NCIT_C190788 NCIT_P208 "CL1799320" @default.
- NCIT_C190788 NCIT_P322 "CTRP" @default.
- NCIT_C190788 NCIT_P322 "GDC" @default.
- NCIT_C190788 normalizedInformationContent "100" @default.
- NCIT_C190788 referenceCount "1" @default.
- NCIT_C190788 hasExactSynonym "ADC SO-N102" @default.
- NCIT_C190788 hasExactSynonym "ADC SOT102" @default.
- NCIT_C190788 hasExactSynonym "Anti-CLDN18.2 ADC SOT102" @default.
- NCIT_C190788 hasExactSynonym "Anti-Claudin 18.2 ADC SOT102" @default.
- NCIT_C190788 hasExactSynonym "Anti-Claudin 18.2 Antibody-drug Conjugate SOT102" @default.
- NCIT_C190788 hasExactSynonym "Anti-Claudin 18.2/PNU ADC SOT102" @default.
- NCIT_C190788 hasExactSynonym "SO N102" @default.
- NCIT_C190788 hasExactSynonym "SO-N102" @default.
- NCIT_C190788 hasExactSynonym "SON102" @default.
- NCIT_C190788 hasExactSynonym "SOT 102" @default.
- NCIT_C190788 hasExactSynonym "SOT-102" @default.
- NCIT_C190788 hasExactSynonym "SOT102" @default.
- NCIT_C190788 inSubset NCIT_C116977 @default.
- NCIT_C190788 inSubset NCIT_C116978 @default.
- NCIT_C190788 inSubset NCIT_C128784 @default.
- NCIT_C190788 inSubset NCIT_C157711 @default.
- NCIT_C190788 inSubset NCIT_C157712 @default.
- NCIT_C190788 inSubset NCIT_C176424 @default.
- NCIT_C190788 type Class @default.
- NCIT_C190788 isDefinedBy ncit.owl @default.
- NCIT_C190788 label "Anti-Claudin 18.2 Antibody-drug Conjugate SOT102" @default.
- NCIT_C190788 subClassOf NCIT_C129821 @default.
- NCIT_C190788 subClassOf NCIT_C129823 @default.
- NCIT_C190788 subClassOf NCIT_C1512 @default.
- NCIT_C190788 subClassOf NCIT_C163758 @default.
- NCIT_C190788 subClassOf NCIT_C190788 @default.
- NCIT_C190788 subClassOf NCIT_C1908 @default.
- NCIT_C190788 subClassOf NCIT_C1909 @default.
- NCIT_C190788 subClassOf NCIT_C200250 @default.
- NCIT_C190788 subClassOf NCIT_C200251 @default.
- NCIT_C190788 subClassOf NCIT_C274 @default.
- NCIT_C190788 subClassOf NCIT_C307 @default.
- NCIT_C190788 subClassOf NCIT_C308 @default.