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- NCIT_C190790 IAO_0000115 "A fluorobenzyl polyethylene glycol (PEG) conjugated to tetraiodothyroacetic acid that targets the thyrointegrin alphaVbeta3, with potential antineoplastic activity. Upon administration, the thyrointegrin alphaVbeta3 antagonist fb-PMT targets and binds to alphaVbeta3 integrin. This results in the inhibition of angiogenesis and metastasis. The mechanism of actions (MOAs) through which fb-PMT exerts its actions may be more complex and may be through multiple signaling pathways. AlphaVbeta3 integrin, a cell adhesion and signaling receptor, is overexpressed on the surface of tumor vessel endothelial cells, some tumor cells, and a number of other cell types." @default.
- NCIT_C190790 NCIT_A7 NCIT_C38953 @default.
- NCIT_C190790 NCIT_NHC0 "C190790" @default.
- NCIT_C190790 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C190790 NCIT_P107 "Thyrointegrin AlphaVBeta3 Antagonist fb-PMT" @default.
- NCIT_C190790 NCIT_P108 "Thyrointegrin AlphaVBeta3 Antagonist fb-PMT" @default.
- NCIT_C190790 NCIT_P208 "CL1799321" @default.
- NCIT_C190790 NCIT_P322 "CTRP" @default.
- NCIT_C190790 NCIT_P322 "GDC" @default.
- NCIT_C190790 normalizedInformationContent "100" @default.
- NCIT_C190790 referenceCount "1" @default.
- NCIT_C190790 hasExactSynonym "AlphaV/Beta3 Antagonist fb-PMT" @default.
- NCIT_C190790 hasExactSynonym "Fluorobenzyl Polyethylene Glycol Conjugated Tetraiodothyroacetic Acid" @default.
- NCIT_C190790 hasExactSynonym "NP 100" @default.
- NCIT_C190790 hasExactSynonym "NP 751" @default.
- NCIT_C190790 hasExactSynonym "NP-100" @default.
- NCIT_C190790 hasExactSynonym "NP-751" @default.
- NCIT_C190790 hasExactSynonym "NP100" @default.
- NCIT_C190790 hasExactSynonym "NP751" @default.
- NCIT_C190790 hasExactSynonym "Thyrointegrin AlphaVBeta3 Antagonist fb-PMT" @default.
- NCIT_C190790 hasExactSynonym "fb-PMT" @default.
- NCIT_C190790 inSubset NCIT_C116977 @default.
- NCIT_C190790 inSubset NCIT_C116978 @default.
- NCIT_C190790 inSubset NCIT_C128784 @default.
- NCIT_C190790 inSubset NCIT_C157711 @default.
- NCIT_C190790 inSubset NCIT_C157712 @default.
- NCIT_C190790 inSubset NCIT_C176424 @default.
- NCIT_C190790 type Class @default.
- NCIT_C190790 isDefinedBy ncit.owl @default.
- NCIT_C190790 label "Thyrointegrin AlphaVBeta3 Antagonist fb-PMT" @default.
- NCIT_C190790 subClassOf NCIT_C190790 @default.
- NCIT_C190790 subClassOf NCIT_C1908 @default.
- NCIT_C190790 subClassOf NCIT_C1909 @default.
- NCIT_C190790 subClassOf NCIT_C2189 @default.
- NCIT_C190790 subClassOf NCIT_C274 @default.