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- NCIT_C1910 IAO_0000115 "A synthetic analogue of the endogenous hormone gonadotropin-releasing hormone (GnRH), with potential antineoplastic activity. Upon administration, GnRH analogue mimics endogenous GnRH and strongly binds to and activates pituitary GnRH receptors, which stimulates the synthesis and secretion of the gonadotropic hormones, follicle stimulating hormone (FSH) and luteinizing hormone (LH). Continuous, prolonged activation by the GnRH analogue results in pituitary GnRH receptor desensitization and receptor downregulation. This causes inhibition of pituitary gonadotropin secretion of LH and FSH. In males, the inhibition of LH secretion prevents the production and release of testosterone from Leydig cells in the testes and causes a significant decline in testosterone production that is near the levels seen after castration. This may inhibit androgen receptor-positive tumor progression. In females, this results in a decrease in estradiol production. GnRH, also called luteinizing hormone-releasing hormone (LH-RH), is normally synthesized in and secreted by the hypothalamus. Synthetic analogues of GnRH have a stronger receptor binding affinity than the endogenous form." @default.
- NCIT_C1910 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1910 NCIT_NHC0 "C1910" @default.
- NCIT_C1910 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1910 NCIT_P107 "Gonadotropin-releasing Hormone Analog" @default.
- NCIT_C1910 NCIT_P108 "Gonadotropin-releasing Hormone Analog" @default.
- NCIT_C1910 NCIT_P207 "C1268900" @default.
- NCIT_C1910 NCIT_P322 "CTRP" @default.
- NCIT_C1910 NCIT_P322 "GDC" @default.
- NCIT_C1910 NCIT_P325 "A substance that keeps the testicles and ovaries from making sex hormones by blocking other hormones that are needed to make them. In men, gonadotropin-releasing hormone agonists cause the testicles to stop making testosterone. In women, they cause the ovaries to stop making estrogen and progesterone. Some gonadotropin-releasing hormone agonists are used to treat prostate cancer. Also called GnRH agonist, LH-RH agonist, and luteinizing hormone-releasing hormone agonist." @default.
- NCIT_C1910 NCIT_P329 "42628" @default.
- NCIT_C1910 NCIT_P330 "42628" @default.
- NCIT_C1910 NCIT_P366 "Luteinizing_Hormone-releasing_Hormone_Agonist" @default.
- NCIT_C1910 NCIT_P375 "Gonadotropin-releasing Hormone Analog" @default.
- NCIT_C1910 NCIT_P399 "42628" @default.
- NCIT_C1910 normalizedInformationContent "69.267312417103497" @default.
- NCIT_C1910 referenceCount "104" @default.
- NCIT_C1910 hasExactSynonym "GnRH Agonist" @default.
- NCIT_C1910 hasExactSynonym "GnRH Analog" @default.
- NCIT_C1910 hasExactSynonym "Gonadotropin-Releasing Hormone Agonist" @default.
- NCIT_C1910 hasExactSynonym "Gonadotropin-Releasing Hormone Analogue" @default.
- NCIT_C1910 hasExactSynonym "Gonadotropin-releasing Hormone Analog" @default.
- NCIT_C1910 hasExactSynonym "LH-RH Analogs" @default.
- NCIT_C1910 hasExactSynonym "LH-RH agonist" @default.
- NCIT_C1910 hasExactSynonym "LHRH Agonist" @default.
- NCIT_C1910 hasExactSynonym "Luteinizing Hormone-Releasing Hormone Analog" @default.
- NCIT_C1910 hasExactSynonym "gonadotropin-releasing hormone agonist" @default.
- NCIT_C1910 hasExactSynonym "luteinizing hormone-releasing hormone agonist" @default.
- NCIT_C1910 inSubset NCIT_C116977 @default.
- NCIT_C1910 inSubset NCIT_C116978 @default.
- NCIT_C1910 inSubset NCIT_C128784 @default.
- NCIT_C1910 inSubset NCIT_C157711 @default.
- NCIT_C1910 inSubset NCIT_C157712 @default.
- NCIT_C1910 inSubset NCIT_C176424 @default.
- NCIT_C1910 inSubset NCIT_C177537 @default.
- NCIT_C1910 type Class @default.
- NCIT_C1910 isDefinedBy ncit.owl @default.
- NCIT_C1910 label "Gonadotropin-releasing Hormone Analog" @default.
- NCIT_C1910 subClassOf NCIT_C147908 @default.
- NCIT_C1910 subClassOf NCIT_C1908 @default.
- NCIT_C1910 subClassOf NCIT_C1909 @default.
- NCIT_C1910 subClassOf NCIT_C1910 @default.
- NCIT_C1910 subClassOf NCIT_C548 @default.