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- NCIT_C191648 IAO_0000115 "An orally bioavailable inhibitor of all members of the serine/threonine protein kinase Raf family, including A-Raf, B-Raf and C-Raf protein kinases, with potential antineoplastic activity. Upon oral administration, pan-RAF inhibitor JZP815 selectively binds to and inhibits the activity of wild-type and mutated forms of Raf, including B-Raf mutations, and B-Raf fusions. This prevents the activation of Raf-mediated signal transduction pathways, which may inhibit tumor cell growth. Oncogenic mutations in Raf plays a key role in the overactivation of the Ras-mitogen-activated protein kinase (MAPK) pathway and drives tumor cell proliferation and survival." @default.
- NCIT_C191648 NCIT_A7 NCIT_C17476 @default.
- NCIT_C191648 NCIT_A7 NCIT_C17484 @default.
- NCIT_C191648 NCIT_NHC0 "C191648" @default.
- NCIT_C191648 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C191648 NCIT_P107 "pan-RAF Inhibitor JZP815" @default.
- NCIT_C191648 NCIT_P108 "pan-RAF Inhibitor JZP815" @default.
- NCIT_C191648 NCIT_P208 "CL1904931" @default.
- NCIT_C191648 NCIT_P322 "CTRP" @default.
- NCIT_C191648 NCIT_P322 "GDC" @default.
- NCIT_C191648 normalizedInformationContent "100" @default.
- NCIT_C191648 referenceCount "1" @default.
- NCIT_C191648 hasExactSynonym "JZP 815" @default.
- NCIT_C191648 hasExactSynonym "JZP-815" @default.
- NCIT_C191648 hasExactSynonym "JZP815" @default.
- NCIT_C191648 hasExactSynonym "RAF Inhibitor JZP815" @default.
- NCIT_C191648 hasExactSynonym "pan-RAF Inhibitor JZP815" @default.
- NCIT_C191648 inSubset NCIT_C116977 @default.
- NCIT_C191648 inSubset NCIT_C116978 @default.
- NCIT_C191648 inSubset NCIT_C128784 @default.
- NCIT_C191648 inSubset NCIT_C157711 @default.
- NCIT_C191648 inSubset NCIT_C157712 @default.
- NCIT_C191648 inSubset NCIT_C176424 @default.
- NCIT_C191648 type Class @default.
- NCIT_C191648 isDefinedBy ncit.owl @default.
- NCIT_C191648 label "pan-RAF Inhibitor JZP815" @default.
- NCIT_C191648 subClassOf NCIT_C129824 @default.
- NCIT_C191648 subClassOf NCIT_C129825 @default.
- NCIT_C191648 subClassOf NCIT_C1404 @default.
- NCIT_C191648 subClassOf NCIT_C163758 @default.
- NCIT_C191648 subClassOf NCIT_C1908 @default.
- NCIT_C191648 subClassOf NCIT_C1909 @default.
- NCIT_C191648 subClassOf NCIT_C191648 @default.
- NCIT_C191648 subClassOf NCIT_C2189 @default.
- NCIT_C191648 subClassOf NCIT_C2336 @default.
- NCIT_C191648 subClassOf NCIT_C274 @default.
- NCIT_C191648 subClassOf NCIT_C471 @default.
- NCIT_C191648 subClassOf NCIT_C61074 @default.