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- NCIT_C191757 IAO_0000115 "An engineered monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CLDN18.2 monoclonal antibody ZL-1211 specifically targets and binds to CLDN18.2 expressed on tumor cells. The binding induces antibody-dependent cellular cytotoxicity (ADCC) and activates innate and adaptive immunity. This kills and inhibits proliferation of CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C191757 NCIT_A7 NCIT_C150412 @default.
- NCIT_C191757 NCIT_NHC0 "C191757" @default.
- NCIT_C191757 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C191757 NCIT_P107 "Anti-CLDN18.2 Monoclonal Antibody ZL-1211" @default.
- NCIT_C191757 NCIT_P108 "Anti-CLDN18.2 Monoclonal Antibody ZL-1211" @default.
- NCIT_C191757 NCIT_P208 "CL1905176" @default.
- NCIT_C191757 NCIT_P322 "CTRP" @default.
- NCIT_C191757 NCIT_P322 "GDC" @default.
- NCIT_C191757 NCIT_R124 NCIT_C17710 @default.
- NCIT_C191757 NCIT_R124 NCIT_C17828 @default.
- NCIT_C191757 NCIT_R124 NCIT_C18219 @default.
- NCIT_C191757 NCIT_R124 NCIT_C19986 @default.
- NCIT_C191757 NCIT_R124 NCIT_C40474 @default.
- NCIT_C191757 normalizedInformationContent "100" @default.
- NCIT_C191757 referenceCount "1" @default.
- NCIT_C191757 hasExactSynonym "Anti-CLDN18.2 Monoclonal Antibody ZL-1211" @default.
- NCIT_C191757 hasExactSynonym "Anti-Claudin18.2 Monoclonal Antibody ZL-1211" @default.
- NCIT_C191757 hasExactSynonym "ZL 1211" @default.
- NCIT_C191757 hasExactSynonym "ZL-1211" @default.
- NCIT_C191757 hasExactSynonym "ZL1211" @default.
- NCIT_C191757 inSubset NCIT_C116977 @default.
- NCIT_C191757 inSubset NCIT_C116978 @default.
- NCIT_C191757 inSubset NCIT_C128784 @default.
- NCIT_C191757 inSubset NCIT_C157711 @default.
- NCIT_C191757 inSubset NCIT_C157712 @default.
- NCIT_C191757 inSubset NCIT_C176424 @default.
- NCIT_C191757 type Class @default.
- NCIT_C191757 isDefinedBy ncit.owl @default.
- NCIT_C191757 label "Anti-CLDN18.2 Monoclonal Antibody ZL-1211" @default.
- NCIT_C191757 subClassOf NCIT_C129821 @default.
- NCIT_C191757 subClassOf NCIT_C129822 @default.
- NCIT_C191757 subClassOf NCIT_C163758 @default.
- NCIT_C191757 subClassOf NCIT_C179676 @default.
- NCIT_C191757 subClassOf NCIT_C1908 @default.
- NCIT_C191757 subClassOf NCIT_C1909 @default.
- NCIT_C191757 subClassOf NCIT_C191757 @default.
- NCIT_C191757 subClassOf NCIT_C200250 @default.
- NCIT_C191757 subClassOf NCIT_C20401 @default.
- NCIT_C191757 subClassOf NCIT_C274 @default.
- NCIT_C191757 subClassOf NCIT_C307 @default.
- NCIT_C191757 subClassOf NCIT_C308 @default.