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- NCIT_C191847 IAO_0000115 "A fourth-generation, orally bioavailable, mutant-selective epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration, EGFR mutant-selective inhibitor H002 targets, binds to, and inhibits the activity of EGFR, including multiple EGFR resistance mutations, such as single mutations, including Del19 and L858R, double mutations, including Del19/C797S, L858R/C797S, Del19/T790M and L858R/T790M, and triple mutations, including Del19/T790M/C797S and L858R/T790M/C797S. This prevents EGFR mutant-mediated signaling, which induces cell death and inhibits tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.
- NCIT_C191847 NCIT_A7 NCIT_C126892 @default.
- NCIT_C191847 NCIT_A7 NCIT_C147011 @default.
- NCIT_C191847 NCIT_A7 NCIT_C98515 @default.
- NCIT_C191847 NCIT_NHC0 "C191847" @default.
- NCIT_C191847 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C191847 NCIT_P108 "EGFR Mutant-selective Inhibitor H002" @default.
- NCIT_C191847 NCIT_P208 "CL1905143" @default.
- NCIT_C191847 NCIT_P322 "GDC" @default.
- NCIT_C191847 NCIT_P399 "811165" @default.
- NCIT_C191847 normalizedInformationContent "100" @default.
- NCIT_C191847 referenceCount "1" @default.
- NCIT_C191847 hasExactSynonym "EGFR Inhibitor H002" @default.
- NCIT_C191847 hasExactSynonym "EGFR Mutant-selective Inhibitor H002" @default.
- NCIT_C191847 hasExactSynonym "H 002" @default.
- NCIT_C191847 hasExactSynonym "H-002" @default.
- NCIT_C191847 hasExactSynonym "H002" @default.
- NCIT_C191847 inSubset NCIT_C128784 @default.
- NCIT_C191847 inSubset NCIT_C157711 @default.
- NCIT_C191847 inSubset NCIT_C157712 @default.
- NCIT_C191847 inSubset NCIT_C176424 @default.
- NCIT_C191847 type Class @default.
- NCIT_C191847 isDefinedBy ncit.owl @default.
- NCIT_C191847 label "EGFR Mutant-selective Inhibitor H002" @default.
- NCIT_C191847 subClassOf NCIT_C129824 @default.
- NCIT_C191847 subClassOf NCIT_C129825 @default.
- NCIT_C191847 subClassOf NCIT_C1404 @default.
- NCIT_C191847 subClassOf NCIT_C163758 @default.
- NCIT_C191847 subClassOf NCIT_C163952 @default.
- NCIT_C191847 subClassOf NCIT_C1908 @default.
- NCIT_C191847 subClassOf NCIT_C1909 @default.
- NCIT_C191847 subClassOf NCIT_C191847 @default.
- NCIT_C191847 subClassOf NCIT_C1967 @default.
- NCIT_C191847 subClassOf NCIT_C2167 @default.
- NCIT_C191847 subClassOf NCIT_C2189 @default.
- NCIT_C191847 subClassOf NCIT_C274 @default.
- NCIT_C191847 subClassOf NCIT_C471 @default.