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- NCIT_C191850 IAO_0000115 "An antibody drug conjugate (ADC) composed of an afucosylated immunoglobulin G1 (IgG1) monoclonal antibody directed against the B-cell-specific membrane protein CD19 conjugated to a glucocorticoid receptor (GR) modulator (GRM), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19-GRM ADC ABBV-319 targets and binds to CD19. thereby inducing antibody-dependent cellular cytotoxicity (ADCC). Additionally, by delivering the GRM payload directly to CD19-expressing tumor cells, ABBV-319 inhibits the activation of GR-dependent expression of proliferative and anti-apoptotic genes. This induces apoptosis and inhibits tumor cell proliferation in CD19-expressing tumor cells. CD19 is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies and drives B-cell proliferation. GRMs show robust anti-tumor activity against B-cell malignancies." @default.
- NCIT_C191850 NCIT_A7 NCIT_C38894 @default.
- NCIT_C191850 NCIT_NHC0 "C191850" @default.
- NCIT_C191850 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C191850 NCIT_P107 "Anti-CD19-Glucosteroid Receptor Modulator ADC ABBV-31" @default.
- NCIT_C191850 NCIT_P108 "Anti-CD19-Glucosteroid Receptor Modulator ADC ABBV-31" @default.
- NCIT_C191850 NCIT_P208 "CL1905147" @default.
- NCIT_C191850 NCIT_P322 "CTRP" @default.
- NCIT_C191850 NCIT_P322 "GDC" @default.
- NCIT_C191850 NCIT_P399 "811170" @default.
- NCIT_C191850 normalizedInformationContent "100" @default.
- NCIT_C191850 referenceCount "1" @default.
- NCIT_C191850 hasExactSynonym "ABBV 319" @default.
- NCIT_C191850 hasExactSynonym "ABBV-319" @default.
- NCIT_C191850 hasExactSynonym "ABBV319" @default.
- NCIT_C191850 hasExactSynonym "ADC ABBV-319" @default.
- NCIT_C191850 hasExactSynonym "Anti-CD19-GRM ADC ABBV-319" @default.
- NCIT_C191850 hasExactSynonym "Anti-CD19-GRM Antibody-drug Conjugate ABBV-319" @default.
- NCIT_C191850 hasExactSynonym "Anti-CD19-Glucosteroid Receptor Modulator ADC ABBV-31" @default.
- NCIT_C191850 inSubset NCIT_C116977 @default.
- NCIT_C191850 inSubset NCIT_C116978 @default.
- NCIT_C191850 inSubset NCIT_C128784 @default.
- NCIT_C191850 inSubset NCIT_C157711 @default.
- NCIT_C191850 inSubset NCIT_C157712 @default.
- NCIT_C191850 inSubset NCIT_C176424 @default.
- NCIT_C191850 type Class @default.
- NCIT_C191850 isDefinedBy ncit.owl @default.
- NCIT_C191850 label "Anti-CD19-Glucosteroid Receptor Modulator ADC ABBV-31" @default.
- NCIT_C191850 subClassOf NCIT_C129821 @default.
- NCIT_C191850 subClassOf NCIT_C129823 @default.
- NCIT_C191850 subClassOf NCIT_C1512 @default.
- NCIT_C191850 subClassOf NCIT_C163758 @default.
- NCIT_C191850 subClassOf NCIT_C1908 @default.
- NCIT_C191850 subClassOf NCIT_C1909 @default.
- NCIT_C191850 subClassOf NCIT_C191850 @default.
- NCIT_C191850 subClassOf NCIT_C198634 @default.
- NCIT_C191850 subClassOf NCIT_C198859 @default.
- NCIT_C191850 subClassOf NCIT_C274 @default.
- NCIT_C191850 subClassOf NCIT_C307 @default.
- NCIT_C191850 subClassOf NCIT_C308 @default.