Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C191851> ?p ?o ?g. }
Showing items 1 to 40 of
40
with 100 items per page.
- NCIT_C191851 IAO_0000115 "An antibody-drug conjugate (ADC) composed of an asymmetric, bivalent, biparatopic antibody targeting two independent epitopes of folate receptor alpha (FRa; FolRa; FOLR1) that is conjugated, via a cleavable peptide linker, to the cytotoxic maytansinoid derivative DM21, with potential antineoplastic activity. Upon administration of anti-FRa/DM21 ADC IMGN151, the antibody moiety targets and binds to FRa expressed on tumor cells. Upon cellular uptake and internalization, DM21 is released, binds to tubulin and disrupts microtubule assembly/disassembly dynamics, which results in the inhibition of both cell division and cell growth of tumor cells. FRa is a glycosylphosphatidylinositol-linked cell surface glycoprotein, that is widely expressed in certain cancers while its expression is limited in normal tissues." @default.
- NCIT_C191851 NCIT_A7 NCIT_C39284 @default.
- NCIT_C191851 NCIT_NHC0 "C191851" @default.
- NCIT_C191851 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C191851 NCIT_P107 "Anti-FRa/DM21 ADC IMGN151" @default.
- NCIT_C191851 NCIT_P108 "Anti-FRa/DM21 ADC IMGN151" @default.
- NCIT_C191851 NCIT_P208 "CL1905146" @default.
- NCIT_C191851 NCIT_P322 "CTRP" @default.
- NCIT_C191851 NCIT_P322 "GDC" @default.
- NCIT_C191851 NCIT_P399 "811248" @default.
- NCIT_C191851 normalizedInformationContent "100" @default.
- NCIT_C191851 referenceCount "1" @default.
- NCIT_C191851 hasExactSynonym "Anti-FRa ADC IMGN151" @default.
- NCIT_C191851 hasExactSynonym "Anti-FRa/DM21 ADC IMGN151" @default.
- NCIT_C191851 hasExactSynonym "Anti-Folate Receptor Alpha ADC IMGN151" @default.
- NCIT_C191851 hasExactSynonym "Antibody-drug Conjugate IMGN151" @default.
- NCIT_C191851 hasExactSynonym "IMGN 151" @default.
- NCIT_C191851 hasExactSynonym "IMGN-151" @default.
- NCIT_C191851 hasExactSynonym "IMGN151" @default.
- NCIT_C191851 inSubset NCIT_C116977 @default.
- NCIT_C191851 inSubset NCIT_C116978 @default.
- NCIT_C191851 inSubset NCIT_C128784 @default.
- NCIT_C191851 inSubset NCIT_C157711 @default.
- NCIT_C191851 inSubset NCIT_C157712 @default.
- NCIT_C191851 inSubset NCIT_C176424 @default.
- NCIT_C191851 type Class @default.
- NCIT_C191851 isDefinedBy ncit.owl @default.
- NCIT_C191851 label "Anti-FRa/DM21 ADC IMGN151" @default.
- NCIT_C191851 subClassOf NCIT_C129821 @default.
- NCIT_C191851 subClassOf NCIT_C129823 @default.
- NCIT_C191851 subClassOf NCIT_C1512 @default.
- NCIT_C191851 subClassOf NCIT_C163758 @default.
- NCIT_C191851 subClassOf NCIT_C1908 @default.
- NCIT_C191851 subClassOf NCIT_C1909 @default.
- NCIT_C191851 subClassOf NCIT_C191851 @default.
- NCIT_C191851 subClassOf NCIT_C200086 @default.
- NCIT_C191851 subClassOf NCIT_C200114 @default.
- NCIT_C191851 subClassOf NCIT_C274 @default.
- NCIT_C191851 subClassOf NCIT_C307 @default.
- NCIT_C191851 subClassOf NCIT_C308 @default.