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- NCIT_C191954 IAO_0000115 "An immunoglobulin G1 (IgG1) monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), with immune checkpoint inhibitory and antineoplastic activities. Upon administration, tuvonralimab binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system." @default.
- NCIT_C191954 NCIT_A7 NCIT_C17489 @default.
- NCIT_C191954 NCIT_NHC0 "C191954" @default.
- NCIT_C191954 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C191954 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C191954 NCIT_P108 "Tuvonralimab" @default.
- NCIT_C191954 NCIT_P208 "CL1905426" @default.
- NCIT_C191954 NCIT_P210 "2417649-44-4" @default.
- NCIT_C191954 NCIT_P319 "8XWO7LI4LO" @default.
- NCIT_C191954 NCIT_P322 "FDA" @default.
- NCIT_C191954 NCIT_R124 NCIT_C17710 @default.
- NCIT_C191954 NCIT_R124 NCIT_C17828 @default.
- NCIT_C191954 NCIT_R124 NCIT_C18219 @default.
- NCIT_C191954 NCIT_R124 NCIT_C19986 @default.
- NCIT_C191954 NCIT_R124 NCIT_C40474 @default.
- NCIT_C191954 normalizedInformationContent "100" @default.
- NCIT_C191954 referenceCount "1" @default.
- NCIT_C191954 hasExactSynonym "PBS-105" @default.
- NCIT_C191954 hasExactSynonym "TUVONRALIMAB" @default.
- NCIT_C191954 hasExactSynonym "Tuvonralimab" @default.
- NCIT_C191954 inSubset NCIT_C128784 @default.
- NCIT_C191954 inSubset NCIT_C63923 @default.
- NCIT_C191954 type Class @default.
- NCIT_C191954 isDefinedBy ncit.owl @default.
- NCIT_C191954 label "Tuvonralimab" @default.
- NCIT_C191954 subClassOf NCIT_C128036 @default.
- NCIT_C191954 subClassOf NCIT_C129821 @default.
- NCIT_C191954 subClassOf NCIT_C129822 @default.
- NCIT_C191954 subClassOf NCIT_C141144 @default.
- NCIT_C191954 subClassOf NCIT_C143250 @default.
- NCIT_C191954 subClassOf NCIT_C163758 @default.
- NCIT_C191954 subClassOf NCIT_C1908 @default.
- NCIT_C191954 subClassOf NCIT_C1909 @default.
- NCIT_C191954 subClassOf NCIT_C191738 @default.
- NCIT_C191954 subClassOf NCIT_C191954 @default.
- NCIT_C191954 subClassOf NCIT_C20401 @default.
- NCIT_C191954 subClassOf NCIT_C274 @default.
- NCIT_C191954 subClassOf NCIT_C307 @default.
- NCIT_C191954 subClassOf NCIT_C308 @default.