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- NCIT_C191976 IAO_0000115 "A biologically active lipopolysaccharide-type component of the Gram-negative bacterial cell wall. Lipoteichoic acid (LTA) may bind to cell surfaces non-specifically, through interactions with phospholipids, or specifically, through interactions with CD14 or toll-like receptors (TLR), and then be internalized. Binding to TLR2 may activate the NFkappaB pathway, mitogen-activated protein kinase (MAPK) signaling pathways and phosphoinositide 3-kinase (PI3K) activity. This can result in increased expression of pro-inflammatory cytokines and both pro- and anti-apoptotic genes and may stimulate expression of the immunosuppressive receptor programmed cell death protein 1 (PD-1; PDCD1; CD279). Increased expression of PD-1 promotes binding to its ligands, programmed cell death-1 ligand 1 (PD-L1) or 2 (PD-L2), which stimulates production of the anti-inflammatory cytokine interleukin-10 (IL-10) and leads to inhibition of CD4-positive T-cell proliferation and activity. Additionally, LTA also may induce cancer cell proliferation in certain susceptible tumor cells while having an inhibitory effect on proliferation of other cancer cells. Lastly, LTA levels in patient samples may also be correlated with inflammatory damage during acute bacterial infections." @default.
- NCIT_C191976 NCIT_NHC0 "C191976" @default.
- NCIT_C191976 NCIT_P106 "Organic Chemical" @default.
- NCIT_C191976 NCIT_P107 "Lipoteichoic Acid" @default.
- NCIT_C191976 NCIT_P108 "Lipoteichoic Acid" @default.
- NCIT_C191976 NCIT_P208 "CL1905432" @default.
- NCIT_C191976 NCIT_P210 "56411-57-5" @default.
- NCIT_C191976 NCIT_P322 "CTRP" @default.
- NCIT_C191976 NCIT_P368 "CHEBI:28640" @default.
- NCIT_C191976 normalizedInformationContent "100" @default.
- NCIT_C191976 referenceCount "1" @default.
- NCIT_C191976 hasExactSynonym "(2s)-1-({3-O-[2-(Acetylamino)-4-Amino-2,4,6-Trideoxy-Beta-D-Galactopyranosyl]-Alpha-D-Glucopyranosyl}oxy)-3-(Heptanoyloxy)propan-2-Yl (7z)-Pentadec-7-Enoate" @default.
- NCIT_C191976 hasExactSynonym "LTA" @default.
- NCIT_C191976 hasExactSynonym "Lipoteichoic Acid" @default.
- NCIT_C191976 hasExactSynonym "[(2S)-1-[(2S,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-3-acetamido-5-amino-4-hydroxy-6-methyloxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-heptanoyloxypropan-2-yl] (E)-pentadec-7-enoate" @default.
- NCIT_C191976 inSubset NCIT_C116977 @default.
- NCIT_C191976 inSubset NCIT_C142799 @default.
- NCIT_C191976 type Class @default.
- NCIT_C191976 isDefinedBy ncit.owl @default.
- NCIT_C191976 label "Lipoteichoic Acid" @default.
- NCIT_C191976 subClassOf NCIT_C1908 @default.
- NCIT_C191976 subClassOf NCIT_C1913 @default.
- NCIT_C191976 subClassOf NCIT_C191976 @default.
- NCIT_C191976 subClassOf NCIT_C616 @default.
- NCIT_C191976 subClassOf NCIT_C718 @default.