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- NCIT_C192005 IAO_0000115 "An orally bioavailable, mutant-selective, fourth-generation epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration, EGFR mutant-selective inhibitor QLH11811 targets, binds to and inhibits the activity of EGFR with selective mutations, including ex19del, L858R, T790M and C797S, thereby preventing EGFR mutant-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR mutant-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.
- NCIT_C192005 NCIT_A7 NCIT_C126892 @default.
- NCIT_C192005 NCIT_A7 NCIT_C147011 @default.
- NCIT_C192005 NCIT_A7 NCIT_C98503 @default.
- NCIT_C192005 NCIT_A7 NCIT_C98515 @default.
- NCIT_C192005 NCIT_NHC0 "C192005" @default.
- NCIT_C192005 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C192005 NCIT_P108 "EGFR Mutant-selective Inhibitor QLH11811" @default.
- NCIT_C192005 NCIT_P208 "CL1905410" @default.
- NCIT_C192005 NCIT_P322 "GDC" @default.
- NCIT_C192005 NCIT_P399 "811249" @default.
- NCIT_C192005 normalizedInformationContent "100" @default.
- NCIT_C192005 referenceCount "1" @default.
- NCIT_C192005 hasExactSynonym "EGFR Inhibitor QLH11811" @default.
- NCIT_C192005 hasExactSynonym "EGFR Mutant-selective Inhibitor QLH11811" @default.
- NCIT_C192005 hasExactSynonym "QLH 11811" @default.
- NCIT_C192005 hasExactSynonym "QLH-11811" @default.
- NCIT_C192005 hasExactSynonym "QLH11811" @default.
- NCIT_C192005 inSubset NCIT_C128784 @default.
- NCIT_C192005 inSubset NCIT_C157711 @default.
- NCIT_C192005 inSubset NCIT_C157712 @default.
- NCIT_C192005 inSubset NCIT_C176424 @default.
- NCIT_C192005 type Class @default.
- NCIT_C192005 isDefinedBy ncit.owl @default.
- NCIT_C192005 label "EGFR Mutant-selective Inhibitor QLH11811" @default.
- NCIT_C192005 subClassOf NCIT_C129824 @default.
- NCIT_C192005 subClassOf NCIT_C129825 @default.
- NCIT_C192005 subClassOf NCIT_C1404 @default.
- NCIT_C192005 subClassOf NCIT_C163758 @default.
- NCIT_C192005 subClassOf NCIT_C163952 @default.
- NCIT_C192005 subClassOf NCIT_C1908 @default.
- NCIT_C192005 subClassOf NCIT_C1909 @default.
- NCIT_C192005 subClassOf NCIT_C192005 @default.
- NCIT_C192005 subClassOf NCIT_C1967 @default.
- NCIT_C192005 subClassOf NCIT_C2167 @default.
- NCIT_C192005 subClassOf NCIT_C2189 @default.
- NCIT_C192005 subClassOf NCIT_C274 @default.
- NCIT_C192005 subClassOf NCIT_C471 @default.