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- NCIT_C192011 IAO_0000115 "A humanized immunoglobulin G1 (IgG1) bispecific antibody targeting both the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2) and the costimulatory receptor 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential immunostimulating and antineoplastic activities. Upon administration, anti-HER2/4-1BB bispecific antibody YH32367 simultaneously targets and binds to HER2 expressed on tumor cells and 4-1BB expressed on activated T-lymphocytes and natural killer (NK) cells. This crosslinks HER2-expressing tumor cells and 4-1BB-expressing T-cells and NK cells, and activates 4-1BB signaling locally in the tumor microenvironment (TME). This results in cytotoxic T-cell co-stimulation and enhances T-lymphocyte-mediated anti-tumor activity. YH32367 also promotes the secretion of interferon-gamma (IFNg) from T-cells, which leads to tumor cell lysis. In addition, the binding of YH32367 to HER2 prevents HER2-mediated signaling. This inhibits the proliferation of HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity." @default.
- NCIT_C192011 NCIT_A7 NCIT_C105113 @default.
- NCIT_C192011 NCIT_A7 NCIT_C17319 @default.
- NCIT_C192011 NCIT_NHC0 "C192011" @default.
- NCIT_C192011 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C192011 NCIT_P108 "Anti-HER2/4-1BB Bispecific Antibody YH32367" @default.
- NCIT_C192011 NCIT_P208 "CL1905405" @default.
- NCIT_C192011 NCIT_P322 "GDC" @default.
- NCIT_C192011 NCIT_P399 "811250" @default.
- NCIT_C192011 NCIT_R124 NCIT_C17710 @default.
- NCIT_C192011 NCIT_R124 NCIT_C17828 @default.
- NCIT_C192011 NCIT_R124 NCIT_C18219 @default.
- NCIT_C192011 NCIT_R124 NCIT_C19986 @default.
- NCIT_C192011 NCIT_R124 NCIT_C40474 @default.
- NCIT_C192011 normalizedInformationContent "100" @default.
- NCIT_C192011 referenceCount "1" @default.
- NCIT_C192011 hasExactSynonym "ABL 105" @default.
- NCIT_C192011 hasExactSynonym "ABL-105" @default.
- NCIT_C192011 hasExactSynonym "ABL105" @default.
- NCIT_C192011 hasExactSynonym "Anti-HER2/4-1BB Bispecific Antibody ABL105" @default.
- NCIT_C192011 hasExactSynonym "Anti-HER2/4-1BB Bispecific Antibody YH32367" @default.
- NCIT_C192011 hasExactSynonym "Anti-HER2/Anti-4-1BB Bispecific Antibody YH32367" @default.
- NCIT_C192011 hasExactSynonym "HER2 x 4-1BB Bispecific Antibody YH32367" @default.
- NCIT_C192011 hasExactSynonym "YH 32367" @default.
- NCIT_C192011 hasExactSynonym "YH-32367" @default.
- NCIT_C192011 hasExactSynonym "YH32367" @default.
- NCIT_C192011 inSubset NCIT_C128784 @default.
- NCIT_C192011 inSubset NCIT_C157711 @default.
- NCIT_C192011 inSubset NCIT_C157712 @default.
- NCIT_C192011 inSubset NCIT_C176424 @default.
- NCIT_C192011 type Class @default.
- NCIT_C192011 isDefinedBy ncit.owl @default.
- NCIT_C192011 label "Anti-HER2/4-1BB Bispecific Antibody YH32367" @default.
- NCIT_C192011 subClassOf NCIT_C129820 @default.
- NCIT_C192011 subClassOf NCIT_C129821 @default.
- NCIT_C192011 subClassOf NCIT_C129822 @default.
- NCIT_C192011 subClassOf NCIT_C1454 @default.
- NCIT_C192011 subClassOf NCIT_C155711 @default.
- NCIT_C192011 subClassOf NCIT_C155745 @default.
- NCIT_C192011 subClassOf NCIT_C163758 @default.
- NCIT_C192011 subClassOf NCIT_C163760 @default.
- NCIT_C192011 subClassOf NCIT_C1908 @default.
- NCIT_C192011 subClassOf NCIT_C1909 @default.
- NCIT_C192011 subClassOf NCIT_C192011 @default.
- NCIT_C192011 subClassOf NCIT_C192997 @default.
- NCIT_C192011 subClassOf NCIT_C20401 @default.
- NCIT_C192011 subClassOf NCIT_C274 @default.
- NCIT_C192011 subClassOf NCIT_C28227 @default.
- NCIT_C192011 subClassOf NCIT_C307 @default.
- NCIT_C192011 subClassOf NCIT_C308 @default.