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- NCIT_C192024 IAO_0000115 "A noncovalent conjugate consisting of the cytokine interleukin-2 (IL-2; IL2) and TCB2, a humanized antibody directed against the IL-2 receptor subunit alpha (IL2Ra; CD25) binding site on IL-2, with potential immunomodulatory and antineoplastic activities. Upon administration of IL-2/anti-IL-2 antibody conjugate SLC-3010, the IL-2 moiety binds to the IL-2 receptor beta (CD122) and gamma (CD132) subunit (IL2Rb/g) expressed on CD8+ T effector cells and natural killer (NK) cells, thereby activating IL2Rb/g-mediated signaling within these immune cells. This activates cytotoxic T-lymphocytes (CTLs) and NK cells and induces expression of certain cytotoxic cytokines, such as interferon-gamma (IFNg) and transforming growth factor-beta (TGFb). This leads to T-cell-mediated cytotoxic immune responses against tumor cells and inhibition of tumor cell proliferation. The TCB2 moiety binds to the IL2Ra binding site on IL-2, preventing the binding of IL-2 to IL2Ra expressed on regulatory T-lymphocytes (Tregs). Signaling through IL2Ra activates CD4-positive immunosuppressive Tregs, which would suppress tumor cell killing. In addition, the binding of the TCB2 moiety to IL-2 induces an allosteric effect that increases the binding affinity of IL-2 to the heterodimeric IL2Rb/g, which further activates T-cell-mediated cytotoxic immune responses against tumor cells." @default.
- NCIT_C192024 NCIT_NHC0 "C192024" @default.
- NCIT_C192024 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C192024 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C192024 NCIT_P107 "IL-2/Anti-IL-2 Antibody Conjugate SLC-3010" @default.
- NCIT_C192024 NCIT_P108 "IL-2/Anti-IL-2 Antibody Conjugate SLC-3010" @default.
- NCIT_C192024 NCIT_P208 "CL1905367" @default.
- NCIT_C192024 NCIT_P322 "CTEP" @default.
- NCIT_C192024 NCIT_P322 "GDC" @default.
- NCIT_C192024 NCIT_P399 "811247" @default.
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- NCIT_C192024 NCIT_R146 NCIT_C104679 @default.
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- NCIT_C192024 NCIT_R146 NCIT_C26548 @default.
- NCIT_C192024 normalizedInformationContent "100" @default.
- NCIT_C192024 referenceCount "1" @default.
- NCIT_C192024 hasExactSynonym "IL-2/Anti-IL-2 Antibody Conjugate SLC-3010" @default.
- NCIT_C192024 hasExactSynonym "IL-2/TCB2 Conjugate SLC-3010" @default.
- NCIT_C192024 hasExactSynonym "SLC 3010" @default.
- NCIT_C192024 hasExactSynonym "SLC-3010" @default.
- NCIT_C192024 hasExactSynonym "SLC3010" @default.
- NCIT_C192024 inSubset NCIT_C116977 @default.
- NCIT_C192024 inSubset NCIT_C116978 @default.
- NCIT_C192024 inSubset NCIT_C128784 @default.
- NCIT_C192024 inSubset NCIT_C157711 @default.
- NCIT_C192024 inSubset NCIT_C157712 @default.
- NCIT_C192024 inSubset NCIT_C176424 @default.
- NCIT_C192024 type Class @default.
- NCIT_C192024 isDefinedBy ncit.owl @default.
- NCIT_C192024 label "IL-2/Anti-IL-2 Antibody Conjugate SLC-3010" @default.
- NCIT_C192024 subClassOf NCIT_C1283 @default.
- NCIT_C192024 subClassOf NCIT_C1908 @default.
- NCIT_C192024 subClassOf NCIT_C1909 @default.
- NCIT_C192024 subClassOf NCIT_C192024 @default.
- NCIT_C192024 subClassOf NCIT_C307 @default.
- NCIT_C192024 subClassOf NCIT_C308 @default.
- NCIT_C192024 subClassOf NCIT_C587 @default.
- NCIT_C192024 subClassOf NCIT_C593 @default.