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- NCIT_C192091 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a bispecific antibody targeting both epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (HGFR; c-Met) and conjugated to a topoisomerase-1 inhibitor (TOP1i), with potential antineoplastic activity. Upon administration, anti-EGFR/c-Met/TOP1i ADC AZD9592 simultaneously targets and binds to the extracellular domains of wild-type (WT) or certain mutant forms of both EGFR and c-Met expressed on cancer cells. Upon binding and internalization, the TOP1i moiety is released, binds to TOP1 and stabilizes cleaved DNA-TOP1 complexes. This prevents DNA re-ligation, induces irreversible DNA strand breaks, prevents DNA repair, and leads to cycle arrest and apoptosis specifically in tumor cells expressing EGFR and c-Met. EGFR and c-Met, both upregulated or mutated in a variety of tumor cell types, play key roles in tumor cell proliferation." @default.
- NCIT_C192091 NCIT_A7 NCIT_C17068 @default.
- NCIT_C192091 NCIT_A7 NCIT_C18186 @default.
- NCIT_C192091 NCIT_NHC0 "C192091" @default.
- NCIT_C192091 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C192091 NCIT_P107 "Anti-EGFR/c-Met/TOP1i ADC AZD9592" @default.
- NCIT_C192091 NCIT_P108 "Anti-EGFR/c-Met/TOP1i ADC AZD9592" @default.
- NCIT_C192091 NCIT_P208 "CL1905620" @default.
- NCIT_C192091 NCIT_P322 "CTRP" @default.
- NCIT_C192091 NCIT_P322 "GDC" @default.
- NCIT_C192091 NCIT_P399 "811630" @default.
- NCIT_C192091 normalizedInformationContent "100" @default.
- NCIT_C192091 referenceCount "1" @default.
- NCIT_C192091 hasExactSynonym "AZD 9592" @default.
- NCIT_C192091 hasExactSynonym "AZD-9592" @default.
- NCIT_C192091 hasExactSynonym "AZD9592" @default.
- NCIT_C192091 hasExactSynonym "Anti-EGFR/c-Met ADC AZD9592" @default.
- NCIT_C192091 hasExactSynonym "Anti-EGFR/c-Met/TOP1i ADC AZD9592" @default.
- NCIT_C192091 hasExactSynonym "Bispecific ADC AZD9592" @default.
- NCIT_C192091 inSubset NCIT_C116977 @default.
- NCIT_C192091 inSubset NCIT_C116978 @default.
- NCIT_C192091 inSubset NCIT_C128784 @default.
- NCIT_C192091 inSubset NCIT_C157711 @default.
- NCIT_C192091 inSubset NCIT_C157712 @default.
- NCIT_C192091 inSubset NCIT_C176424 @default.
- NCIT_C192091 type Class @default.
- NCIT_C192091 isDefinedBy ncit.owl @default.
- NCIT_C192091 label "Anti-EGFR/c-Met/TOP1i ADC AZD9592" @default.
- NCIT_C192091 subClassOf NCIT_C129821 @default.
- NCIT_C192091 subClassOf NCIT_C129823 @default.
- NCIT_C192091 subClassOf NCIT_C1512 @default.
- NCIT_C192091 subClassOf NCIT_C163758 @default.
- NCIT_C192091 subClassOf NCIT_C163952 @default.
- NCIT_C192091 subClassOf NCIT_C164000 @default.
- NCIT_C192091 subClassOf NCIT_C1908 @default.
- NCIT_C192091 subClassOf NCIT_C1909 @default.
- NCIT_C192091 subClassOf NCIT_C192091 @default.
- NCIT_C192091 subClassOf NCIT_C201551 @default.
- NCIT_C192091 subClassOf NCIT_C201552 @default.
- NCIT_C192091 subClassOf NCIT_C274 @default.
- NCIT_C192091 subClassOf NCIT_C307 @default.
- NCIT_C192091 subClassOf NCIT_C308 @default.