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- NCIT_C192095 IAO_0000115 "A bispecific antibody targeting both the tumor-associated antigen (TAA) carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5; CEA) and the costimulatory receptor 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CEA/anti-4-1BB bispecific antibody BGB-B167 simultaneously targets and binds to CEA expressed on tumor cells and 4-1BB expressed on activated T-lymphocytes and natural killer (NK) cells. This crosslinks CEA-expressing tumor cells and 4-1BB-expressing T-cells and NK cells, and activates 4-1BB signaling locally in the tumor microenvironment (TME). This results in cytotoxic T-cell co-stimulation, enhances T-lymphocyte-mediated anti-tumor activity and leads to cytotoxic T-cell-mediated lysis of CEA-expressing tumor cells. The binding of BGB-B167 to CEA may also prevent CEA-mediated signaling. CEA is overexpressed by a variety of cancer cell types and plays a key role in cell migration, cell invasion, and cell adhesion. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity." @default.
- NCIT_C192095 NCIT_A7 NCIT_C105113 @default.
- NCIT_C192095 NCIT_A7 NCIT_C16384 @default.
- NCIT_C192095 NCIT_NHC0 "C192095" @default.
- NCIT_C192095 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C192095 NCIT_P107 "Anti-CEA/Anti-4-1BB Bispecific Antibody BGB-B167" @default.
- NCIT_C192095 NCIT_P108 "Anti-CEA/Anti-4-1BB Bispecific Antibody BGB-B167" @default.
- NCIT_C192095 NCIT_P208 "CL1905616" @default.
- NCIT_C192095 NCIT_P322 "CTRP" @default.
- NCIT_C192095 NCIT_P322 "GDC" @default.
- NCIT_C192095 NCIT_P399 "810555" @default.
- NCIT_C192095 NCIT_R124 NCIT_C17710 @default.
- NCIT_C192095 NCIT_R124 NCIT_C17828 @default.
- NCIT_C192095 NCIT_R124 NCIT_C18219 @default.
- NCIT_C192095 NCIT_R124 NCIT_C19986 @default.
- NCIT_C192095 NCIT_R124 NCIT_C40474 @default.
- NCIT_C192095 normalizedInformationContent "100" @default.
- NCIT_C192095 referenceCount "1" @default.
- NCIT_C192095 hasExactSynonym "Anti-4-1BB/CEA Bispecific Antibody BGB-B167" @default.
- NCIT_C192095 hasExactSynonym "Anti-CEA/4-1BB Bispecific Antibody BGB-B167" @default.
- NCIT_C192095 hasExactSynonym "Anti-CEA/Anti-4-1BB Bispecific Antibody BGB-B167" @default.
- NCIT_C192095 hasExactSynonym "Anti-CEACAM5/Anti-CD137 Bispecific Antibody BGB-B167" @default.
- NCIT_C192095 hasExactSynonym "BGB B167" @default.
- NCIT_C192095 hasExactSynonym "BGB-B167" @default.
- NCIT_C192095 hasExactSynonym "BGBB167" @default.
- NCIT_C192095 hasExactSynonym "CEA x 4-1BB Bispecific Antibody BGB-B167" @default.
- NCIT_C192095 inSubset NCIT_C116977 @default.
- NCIT_C192095 inSubset NCIT_C116978 @default.
- NCIT_C192095 inSubset NCIT_C128784 @default.
- NCIT_C192095 inSubset NCIT_C157711 @default.
- NCIT_C192095 inSubset NCIT_C157712 @default.
- NCIT_C192095 inSubset NCIT_C176424 @default.
- NCIT_C192095 type Class @default.
- NCIT_C192095 isDefinedBy ncit.owl @default.
- NCIT_C192095 label "Anti-CEA/Anti-4-1BB Bispecific Antibody BGB-B167" @default.
- NCIT_C192095 subClassOf NCIT_C129820 @default.
- NCIT_C192095 subClassOf NCIT_C129821 @default.
- NCIT_C192095 subClassOf NCIT_C129822 @default.
- NCIT_C192095 subClassOf NCIT_C1454 @default.
- NCIT_C192095 subClassOf NCIT_C155745 @default.
- NCIT_C192095 subClassOf NCIT_C163758 @default.
- NCIT_C192095 subClassOf NCIT_C1908 @default.
- NCIT_C192095 subClassOf NCIT_C1909 @default.
- NCIT_C192095 subClassOf NCIT_C192095 @default.
- NCIT_C192095 subClassOf NCIT_C192997 @default.
- NCIT_C192095 subClassOf NCIT_C200043 @default.
- NCIT_C192095 subClassOf NCIT_C20401 @default.
- NCIT_C192095 subClassOf NCIT_C2456 @default.
- NCIT_C192095 subClassOf NCIT_C274 @default.
- NCIT_C192095 subClassOf NCIT_C28227 @default.
- NCIT_C192095 subClassOf NCIT_C307 @default.
- NCIT_C192095 subClassOf NCIT_C308 @default.