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- NCIT_C192103 IAO_0000115 "An orally bioavailable selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, SERD SCO-120 specifically targets and binds to both wild-type and mutant forms of the estrogen receptor (ER; ERalpha), including the somatic mutations Y537S and D538G. This induces a conformational change that results in ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells. Somatic mutations in the ER gene ESR1, especially Y537S and D538G, have been associated with acquired antiestrogen drug resistance." @default.
- NCIT_C192103 NCIT_A7 NCIT_C38361 @default.
- NCIT_C192103 NCIT_NHC0 "C192103" @default.
- NCIT_C192103 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C192103 NCIT_P107 "Selective Estrogen Receptor Degrader SCO-120" @default.
- NCIT_C192103 NCIT_P108 "Selective Estrogen Receptor Degrader SCO-120" @default.
- NCIT_C192103 NCIT_P208 "CL1905631" @default.
- NCIT_C192103 NCIT_P322 "CTRP" @default.
- NCIT_C192103 NCIT_P322 "GDC" @default.
- NCIT_C192103 NCIT_P399 "811631" @default.
- NCIT_C192103 normalizedInformationContent "100" @default.
- NCIT_C192103 referenceCount "1" @default.
- NCIT_C192103 hasExactSynonym "SCO 120" @default.
- NCIT_C192103 hasExactSynonym "SCO-120" @default.
- NCIT_C192103 hasExactSynonym "SCO120" @default.
- NCIT_C192103 hasExactSynonym "SERD SCO-120" @default.
- NCIT_C192103 hasExactSynonym "Selective Estrogen Receptor Degrader SCO-120" @default.
- NCIT_C192103 inSubset NCIT_C116977 @default.
- NCIT_C192103 inSubset NCIT_C116978 @default.
- NCIT_C192103 inSubset NCIT_C128784 @default.
- NCIT_C192103 inSubset NCIT_C157711 @default.
- NCIT_C192103 inSubset NCIT_C157712 @default.
- NCIT_C192103 inSubset NCIT_C176424 @default.
- NCIT_C192103 type Class @default.
- NCIT_C192103 isDefinedBy ncit.owl @default.
- NCIT_C192103 label "Selective Estrogen Receptor Degrader SCO-120" @default.
- NCIT_C192103 subClassOf NCIT_C129818 @default.
- NCIT_C192103 subClassOf NCIT_C147908 @default.
- NCIT_C192103 subClassOf NCIT_C163758 @default.
- NCIT_C192103 subClassOf NCIT_C1908 @default.
- NCIT_C192103 subClassOf NCIT_C1909 @default.
- NCIT_C192103 subClassOf NCIT_C192103 @default.
- NCIT_C192103 subClassOf NCIT_C2116 @default.
- NCIT_C192103 subClassOf NCIT_C274 @default.
- NCIT_C192103 subClassOf NCIT_C481 @default.
- NCIT_C192103 subClassOf NCIT_C547 @default.